| 紫杉醇联合DDP与奈达铂联合5-FU治疗晚期食管癌的临床观察 |
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| 引用本文： | 张从军,闫敏,孟琼. 紫杉醇联合DDP与奈达铂联合5-FU治疗晚期食管癌的临床观察[J]. 现代肿瘤医学, 2010, 18(1) |
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| 作者姓名： | 张从军 闫敏 孟琼 |
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| 作者单位： | 安徽医科大学第一附属医院肿瘤内科,安徽,合肥,230022 |
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| 摘 要： | 目的:比较紫杉醇联合DDP与奈达铂联合5-FU治疗晚期食管癌的临床疗效及不良反应.方法:48例晚期食管癌随机分组,23例进入TP组(紫杉醇联合DDP),25例进入NF组(奈达铂联合5-FU).TP组:PTX 135-175mg/m2,静脉滴注3小时,d1,DDP 20mg/m2,静脉滴注,d1-5;NF组化疗方案:NDP 80-100mg/m2,静脉滴注2小时,d1,5-FU 500mg/m2,d1-5;每3周为1个周期,至少完成2个周期.结果:TP组和NF组的有效率分别为52.5%和48.0%,两组无统计学差异(P＞0.05).TP组不良反应较NF组明显严重,TP组主要为脱发、中性粒细胞减少、消化道反应、周围神经毒性,NF组主要为消化道反应、中性粒细胞减少.结论:TP方案与NF方案治疗晚期食管癌疗效相似,不良反应可以耐受,均可以用于晚期食管癌的治疗.
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| 关 键 词： | 食管癌 紫杉醇 奈达铂 疗效 不良反应 |
Clinical observation of paclitaxel plus cisplatin and nedaplatin plus 5-fluorouracil in treatment of advanced esophageal carcinoma |
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| ZHANG Cong-jun,YAN Min,MENG Qiong. Clinical observation of paclitaxel plus cisplatin and nedaplatin plus 5-fluorouracil in treatment of advanced esophageal carcinoma[J]. Journal of Modern Oncology, 2010, 18(1) |
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| Authors: | ZHANG Cong-jun YAN Min MENG Qiong |
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| Affiliation: | ZHANG Cong-jun,YAN Min,MENG Qiong Department of Oncology,The First Affiliated Hospital of Anhui Medical University,Hefei 230022,China. |
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| Abstract: | Objective:To evaluate the response and toxicity of paclitaxel(PTX)plus cisplatin(DDP)and nedaplatin(NDP)plus 5-fluorouracil(5-FU)for the patients with advanced esophageal carcinoma.Methods:Forty-eight patients with advanced esophageal carcinoma were divided randomly into two groups.TP group composed of 23 cases were treated with PTX plus DDP,and NF group including 25 cases were treated with NDP plus 5-FU.Patients in TP group were given PTX 135-175mg/m2 by 3-hour infusion on d_1 and DDP 20mg/m2 d_1-5.Patient... |
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| Keywords: | esophageal carcinoma paclitaxel nedaplatin efficacy toxicity |
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