| p21与周期蛋白依赖性激酶2在Bowen病皮损中的表达 |
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| 引用本文： | 尤德渊,蔡丽敏,尤海燕.p21与周期蛋白依赖性激酶2在Bowen病皮损中的表达[J].中华皮肤科杂志,2003,36(11):635-636. |
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| 作者姓名： | 尤德渊 蔡丽敏 尤海燕 |
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| 作者单位： | 1. 150086,哈尔滨医科大学附属第二医院皮肤科
2. 黑龙江省医院皮肤科 |
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| 基金项目： | 黑龙江省自然科学基金资助项目(D9708) |
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| 摘 要： | 目的探讨细胞周期调节蛋白p21及周期蛋白依赖性激酶2(CDK2)在Bowen病中的表达和意义。方法采用链霉亲和素-过氧化物酶法检测28例Bowen病和10例正常人皮肤中p21、CDK2的表达和分布。结果p21与CDK2在Bowen病中均为高表达,而10例正常人皮肤标本中表皮均未见表达。28例Bowen病标本,其中22例(78.6%)呈p21阳性染色,26例(92.9%)呈CDK2阳性染色,两者表达水平呈正相关(r=0.84,P<0.001)。结论Bowen病中肿瘤细胞的增殖能力高于正常细胞,可表达高水平促增殖因子CDK2。p21在Bowen病中的高表达可能与肿瘤细胞的分化有关。
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| 关 键 词： | Bowen病 皮肤肿瘤 p21 周期蛋白依赖性激酶2 免疫组织化学 |
| 修稿时间： | 2002年11月11 |
Expression of p21 and Cyclin-dependent Kinase 2 in Bowen's Disease |
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| YOU De-yuan ,CAI Li-min,YOU Hai-yan.Expression of p21 and Cyclin-dependent Kinase 2 in Bowen''s Disease[J].Chinese Journal of Dermatology,2003,36(11):635-636. |
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| Authors: | YOU De-yuan CAI Li-min YOU Hai-yan |
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| Affiliation: | YOU De-yuan *,CAI Li-min,YOU Hai-yan.* Department of Dermatology,Second Hospital of Harbin Medical University,Harbin150086,China |
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| Abstract: | Objective To explore the expression and implication of p21and cyclin-dependent kinase2(CDK2)in Bowen's disease.Methods The expression and distribution of p21and CDK2on the skin le-sion and normal skin were detected by using immunohistochemical technique streptavidin-peroxidase(SP)in28cases of Bowen's disease and10normal controls.Results p21and CDK2were significantly highly ex-pressed in Bowen' s disease and were not expressed in normal skins.Positive staining was found in22/28(78.6%)of Bowen' s disease for p21and26/28(92.9%)for CDK2.There was a correlation between the expression of p21and CDK2(r =0.84,P<0.001).Conclusion Significantly higher cellular proliferation is found in Bowen's disease than that in normal skin,and tumor cells overexpress CDK2.Overexpression of p21might be related to the differentiation of the tumor. |
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| Keywords: | Bowen's disease Cell cycle proteins Cyclin-dependent kinases |
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