Deficient levels of dietary selenium suppress the antibody response in first and second generation mice |
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| Authors: | S.A. Mulhern G.L. Taylor L.E. Magruder A.R. Vessey |
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| Affiliation: | 1. Food and Drug Administration, Division of Nutrition, Washington, DC 20204, USA;2. Medical College of Virginia, Richmond, VA 23298, USA;3. Laboratory of Clinical Pathology, National Institutes of Health, Bethesda, MD 20205, USA;4. University of Rochester, Rochester, NY 14627 USA |
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| Abstract: | The effect of a selenium-deficient diet during prenatal and postnatal development on the immune response was investigated in the C57BL/6J mouse. When the selenium-deficient diet was administered postweaning, these was no effect on the serum chemistries, primary antibody response, or lymphoid organ weight. However, the secondary antibody response to a T-cell dependent antigen was diminished. Administration of the selenium-deficient diet during gestation, lactation, and postweaning development had no effect on the serum chemistry values or lymphoid organs. However, body weights and primary and secondary antibody responses were reduced. Similar results were obtained in both in vivo and in vitro assay systems. |
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| Keywords: | Selenium deficiency antibody response developmental immunology |
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