| 胞磷胆碱治疗药源性锥外系副作用 |
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| 引用本文： | 刘和祥,成平,黄世勋,王以云.胞磷胆碱治疗药源性锥外系副作用[J].中国新药与临床杂志,2001,20(3):185-187. |
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| 作者姓名： | 刘和祥 成平 黄世勋 王以云 |
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| 作者单位： | 滨州市复退军人医院, |
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| 摘 要： | 目的 :探讨胞磷胆碱对药源性锥外系副作用 (EPS)的疗效。方法 :75例病人分为 2组。胞磷胆碱组 38例 (男性 2 5例 ,女性 13例 ,年龄 2 8a±s9a) ,用胞磷胆碱 0 .5g加入 5%葡萄糖注射液 50 0mL中iv ,gtt ,qd ;对照组 37例 (男性 2 3例 ,女性 14例 ,年龄 2 7a± 7a) ,用 5%葡萄糖注射液 50 0mL ,iv ,gtt ,qd ,疗程均 2wk。治疗期间禁用抗胆碱能等与EPS有关的药物。结果 :胞磷胆碱组和对照组总有效率分别为 92 %和 11% ,经Ridit分析 ,P <0 .0 5。胞磷胆碱组对震颤、肌强直、步态和肌张力障碍效果较好。治疗期间未出现副作用。结论 :胞磷胆碱对药源性EPS具有较好的治疗作用。
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| 关 键 词： | 胞磷胆碱 锥体外束 强安定药 |
| 文章编号： | 1007-7669(2001)03-0185-03 |
Citicoline in treating
neuroleptic-induced extrapyramidal side effect |
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| LIU He-xiang,CHENG Ping,HUANG Shi-Xun,WANG Yi-Yun.Citicoline in treating
neuroleptic-induced extrapyramidal side effect[J].Chinese Journal of New Drugs and Clinical Remedies,2001,20(3):185-187. |
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| Authors: | LIU He-xiang CHENG Ping HUANG Shi-Xun WANG Yi-Yun |
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| Abstract: | AIM：To study the effects of citicoline in treating neuroleptic-induced extrapyramidal side effect (EPS)． METHODS：Seventy-five patients were divided into two groups：citicoline group of 38 patients ( M25，F13；age 28 a±s 9 a) received citicoline injection 0.5 g.d-1，in 5 % glucose injection 500 mL，iv，drip，qd ，for 14 d and control group of 37 patients ( M23，F14；age 27 a±6 a) received 5 % glucose injection 500 mL，iv, drip, qd，for 14 d． RESULTS: The total efficacy of citicoline or control group was 92 % and 11 % (P＜0.05 ), respectively．The tremour, muscular rigidity, gait and muscle dystonia were better in citicoline group than in control group. No side effects were found. CONCLUSION: Citicoline is effective for neuroleptic-induced EPS. |
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| Keywords: | citicoline extrapyramidal tracts major tranquilizing agents [ |
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