Repeat Hepatectomy for Recurrent Colorectal Metastases |
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Authors: | Gen Sugawara Masatoshi Isogai Yuji Kaneoka Masahiko Suzuki Akihiro Yamaguchi |
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Affiliation: | (1) Department of Surgery, Ogaki Municipal Hospital, Ogaki, Japan;(2) Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan |
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Abstract: | Purpose To determine the risks and benefits of repeat hepatectomy for hepatic metastases from colorectal cancer.Methods During a recent 10-year-period, 106 patients underwent hepatectomy for hepatic metastases from colorectal cancer, in our hospital. Recurrence developed in the liver in 57 of these patients, 27 of whom underwent repeat hepatectomy. We reviewed the outcomes of these 27 patients.Results There were three complications after the first hepatectomy and six complications after the second hepatectomy, but there was no perioperative mortality after the first or second hepatectomy. The median survival from the date of second hepatectomy was 41 months with an actuarial 5-year survival rate of 48.7%. Patients who underwent repeat hepatectomy had significantly higher survival rates from the time of first hepatectomy than those who did not. Univariate analysis showed that among the prognostic factors of repeat hepatectomy, only a disease-free interval (DFI) between the first and second hepatectomy of more than 1 year was significantly predictive of a better outcome (P = 0.047).Conclusion Repeat hepatectomy for recurrent colorectal metastases can be performed safely with acceptable mortality and morbidity rates, and can help to extend survival, if the DFI between the first and second hepatectomy is longer than 1 year. |
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Keywords: | Colorectal cancer Liver metastasis Repeat hepatectomy Disease-free interval Extrahepatic metastasis |
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