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木糖氧化产碱菌的耐药性分析
引用本文:张卫英,高英,吴巍,董晓勤,周田美,余道军. 木糖氧化产碱菌的耐药性分析[J]. 中华医院感染学杂志, 2006, 16(5): 589-591
作者姓名:张卫英  高英  吴巍  董晓勤  周田美  余道军
作者单位:1. 杭州市第一人民医院,浙江,杭州,310006
2. 萧山第四人民医院,浙江,杭州,310006
3. 湖州中心医院,浙江,湖州,313000
摘    要:目的调查我院2000年1月~2004年12月5年间木糖氧化产碱菌的分布与耐药现况,为临床合理选用抗菌药物提供参考依据。方法院内分离菌株经VITEK-AMS全自动细菌鉴定仪GNI 卡鉴定到种;药敏试验采用其配套的GNS-KI或GNS-121卡进行耐药分析;部分药敏应用K-B纸片法。结果木糖氧化产碱菌对一、二、三、四代头孢菌素(头孢他啶除外)耐药率>77%;对氨基糖苷类耐药率>76%;对氨苄西林、阿莫西林/克拉维酸、氨苄西林/舒巴坦、头孢西丁、头孢呋辛的耐药率均为100%;对氨曲南耐药率为92.86%;对喹诺酮类药物环丙沙星、左氧氟沙星的耐药率分别为66.67%、44.44%。结论木糖氧化产碱菌检出率呈逐年增多趋势,且呈多重耐药,该菌所致感染应根据细菌药敏试验的结果合理选用抗菌药物。

关 键 词:木糖氧化产碱菌  医院感染  耐药分析
文章编号:1005-4529(2006)05-0589-03
收稿时间:2005-07-10
修稿时间:2005-10-10

Drug Resistance of Alcaligenes xylosoxidans
ZHANG Wei-ying,GAO Ying,WU Wei,DONG Xiao-qin,ZHOU Tian-mei,YU Dao-jun. Drug Resistance of Alcaligenes xylosoxidans[J]. Chinese Journal of Nosocomiology, 2006, 16(5): 589-591
Authors:ZHANG Wei-ying  GAO Ying  WU Wei  DONG Xiao-qin  ZHOU Tian-mei  YU Dao-jun
Abstract:OBJECTIVE To investigate the distribution and the antimicrobial resistance of Alcaligenes xylosoxidans and to provide the guidance of rational use of antibiotics.METHODS A.xylosoxidans was isolated and identified through VITEK-AMS all-automatic microbiology analysis system and its G~-bacilli identification cards(GNI) and drug sensitivity cards(GNS-KI/121) were also analyzed.Drug-resistance was tested by Kirby-Bauer disk(sensitivity) method((Bio-Merieux) and Oxoid products).RESULTS The drug-resistance rates to the 1st to 4th((except) CAZ) generation cephalosporins were more than 77%.The drug-resistance rate to the aminoglycosides was more than 76%,and to(ampicillin,) amoxicillin/CA,ampicillin/sulbactam,cefoxitin and cefuroxime were all 100%;but to(aztreonam) was 92.86%;66.67% and 44.44% strains were resistant to ciprofloxacin and(levofloxacin).(CONCLUSIONS) The detection rates of the multidrug resistant A.xylosoxidans have the tendency to increase yearly.The antibiotics should be used reasonably according to the results of drug sensitivity test in clinic.
Keywords:Alcaligenes xylosoxidans  Nosocomial infection  Drug resistance
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