米非司酮配合化疗药治疗侵蚀性葡萄胎30例临床分析

目的探讨米非司酮配合化疗药在侵蚀性葡萄胎患者治疗中的效果,以寻求较好的药物治疗方式。方法选取2009年1月～2012年8月于本院产科诊断为侵蚀性葡萄胎的患者60例,随机分为实验组和对照组,每组30例。实验组采用米非司酮配合化疗药治疗,对照组采用常规化疗药物治疗,两组在年龄、病因等因素上差异均无统计学意义（P〉0.05）。比较两组患者的治疗效果,以及治疗前后的血清绒毛膜促性腺激素水平。结果实验组有效率为86.7%,对照组有效率为66.7%,实验组有效率高于对照组,差异有统计学意义（P〈0.05）。实验组及对照组患者治疗后血清绒毛膜促性腺激素水平均较治疗前降低,差异有统计学意义（P〈0.05）。实验组患者血清绒毛膜促性腺激素水平,治疗前为（932.4±27.6）U/L,治疗后为（56.8±5.7）U/L,对照组治疗前为（985.2±32.9）U/L,治疗后为（89.5±7.3）U/L,实验组较对照组患者治疗后低,差异有统计学意义（P〈0.05）。结论米非司酮配合化疗药在侵蚀性葡萄胎患者治疗过程中,可有效提高治疗效果,抑制滋养细胞增殖,值得临床推广应用。

Clinical analysis of mifepristone combined with chemotherapy drugs in treatment of 30 cases of patients with invasive mole

Objective To investigate the effect of mifepristone combined with chemotherapy drugs in the treatment of patients with invasive mole and seek better drug treatment.Methods Sixty patients diagnosed with invasive mole in the obstetrics department of our hospital from January 2009 to August 2012 were selected and randomly divided into two groups,with 30 patients in each group.The experimental group was given mifepristone combined with chemotherapy drugs and the control group was given conventional chemotherapy drugs.The two groups of patients were not statistically different in age,pathogen and other factors （P 0.05）.The efficacy and the serum human chorionic gonadotropin levels before and after treatment of the two groups were compared.Results The effective rate of the experimental group （86.7%） was higher than that of the control group （66.7%）,with statistically significant difference （ P 0.05）.The serum human chorionic gonadotropin levels of both experimental group and control group after treatment reduced compared to those before treatment,with statistically significant difference （ P 0.05）.In the experimental group,the serum human chorionic gonadotropin levels was （932.4 ±27.6） U/L before treatment and （56.8 ±5.7） U/L after treatment,and in the control group,the serum human chorionic gonadotropin levels was （985.2 ±32.9） U/L before treatment and （89.5±7.3） U/L after treatment.The experimental group was lower than the control group in the post-treatment serum human chorionic gonadotropin level,with statistically significant difference （P 0.05）.Conclusion In the treatment of patients with invasive mole,mifepristone combined with chemotherapy drugs can effectively improve the therapeutic effect and inhibit the trophoblastic proliferation,thereby is worthy of clinical application.