| 习惯性流产与人类白细胞抗原DQB1基因多态性的相关性 |
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| 引用本文： | 杨旭,阿米娜,王琳.习惯性流产与人类白细胞抗原DQB1基因多态性的相关性[J].中国当代医药,2013(19):51-52. |
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| 作者姓名： | 杨旭 阿米娜 王琳 |
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| 作者单位： | 新疆医科大学第五附属医院妇科,新疆乌鲁木齐830011 |
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| 摘 要： | 目的探讨习惯性流产（HA）与人类白细胞抗原DQB1（HLA-DQB1）基因多态性的关系。方法采用聚合酶链反应-限制性片段长度多态性方法分析60例HA患者和60例正常生育妇女的DQB1基因型。结果 HA组患者的DQB1＊0303等位基因的频率为31.67%,明显高于正常妇女组10.00%的等位基因的频率,差异有统计学意义（χ2=8.54,P〈0.01）。结论 DQB1＊0303单元型可能与HA的发病密切相关。
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| 关 键 词： | 习惯性流产 人类白细胞抗原 多态性 |
Relativity between habitual abortion and human leukocyte antigen DQB1 gene polymorphism |
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| Authors: | YANG Xu A Mi-na WANG Lin |
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| Institution: | Gynecological Department,Fifth Affiliated Hospital of Xinjiang Medical University,Urumqi 830011,China |
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| Abstract: | Objective To discuss the relationship between habitual abortion（HA） and human leukocyte antigen DQB1（HLA-DQB1） gene polymorphism.Methods 60 cases of HA patients and 60 normal fertile women were analyzed by polymerase chain reaction-restriction fragment length polymorphism for DQB1 genotypes.Results Statistical significant difference（χ2=8.54,P0.01） existed in DQB1＊0303 allele frequency between the two groups,with 31.67% in HA pa tients group,significantly higher than 10.00% allele frequency of the control group.Conclusion DQB1＊0303 haplotype may be closely related to the morbidity of HA. |
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| Keywords: | Habitual abortion Human leukocyte antigen Polymorphism |
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