早发型重度子痫前期合并低蛋白血症对妊娠结局的影响

目的探讨早发型重度子痫前期合并低蛋白血症对妊娠结局的影响。方法对140例早发型重度子痫前期患者临床资料进行回顾性分析,根据血浆白蛋白含量将患者分为低蛋白血症组（A组）80例和非低蛋白血症组（B组）60例,比较两组患者的妊娠结局。结果两组患者在年龄、产次和发病孕周方面差异无统计学意义（P〉0.05）;A组妊娠终止孕周和期待治疗天数上早于或少于B组,差异有统计学意义（P〈0.05）;A组孕妇肝酶异常、肾功能损害、浆膜腔积液（胸腹腔积液、心包积液）、心功能不全、产后出血、胎盘早剥等并发症发生率均高于B组,差异具有统计学意义（P〈0.05）;A组患者胎儿宫内生长迟缓、胎儿宫内窘迫、死胎以及新生儿窒息发生率均高于B组,差异有统计学意义（P〈0.05）。结论低蛋白血症可加重早发型重度子痫前期患者病情,导致母婴不良结局。

Influence of early onset severe preeclampsia combined with hypoproteinemia on pregnancy outcome

Objective To investigate the influence of early onset severe preeclampsia combined with hypoproteinemia on pregnancy outcome.Methods 140 cases of early onset severe preeclampsia were analyzed retrospectively.Accord ing to the amount of plasma albumin,they were divided into group A（hypoproteinemia,80 cases） and group B（non-hy poproteinemia,60 cases） respectively.The outcomes of maternal and perinatal between two groups were compared.Results There were no statistically significant differences between two groups in maternal ages,gravidity and gesta tional age at admission（P 0.05）.The gestational age of termination and the duration of treatment were earlier and shorter than those of group B（P0.05）.The maternal complication rates of group A in liver and kidney function dam age,serous cavity edema（splanchnocoele edema,pericardial fluid）,cardiac insufficiency,postpartum hemorrhage and placenta abruption were statistically higher than those of group B（P 0.05）.And the perinatal complication rates of Group A in intrauterine fetal growth retardation,fetal distress in uterus,fetal death and neonate asphyxia were statisti cally higher than those of group B（P0.05）.Conclusion Hypoproteinemia could aggravate the condition of pregnants with early onset severe preeclampsia,which leads to adverse outcomes to pregnants and perinatals.