| 外耳道乳头状瘤人乳头瘤病毒DNA的研究 |
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| 引用本文： | 夏明玉,朱文元.外耳道乳头状瘤人乳头瘤病毒DNA的研究[J].中华皮肤科杂志,1994,27(6):349-350,T002. |
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| 作者姓名： | 夏明玉 朱文元 |
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| 作者单位： | 南京医科大学电镜室!邮政编码210029(夏明玉，卢勤)，南京医科大学附属医院皮肤科(朱文元，范卫新)，南京医科大学附属医院五官科(陆锦玉，程雷) |
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| 摘 要： | 研究了１４例外耳道乳头状瘤的１５个皮损，组织病理学上所有病例均呈乳头瘤样增生，５例在棘层上方有少数灶性空泡细胞，空泡细胞的超微结构发现其染色质周围颗粒和染色质间颗粒数增多，核小体易见，未发现典型的病毒颗粒。用聚合酶链反应检测发现所有标本均含有ＨＰＶ６，未发现有ＨＰＶＳ、１１、１６、１８、３１和３３。结果说明外耳道乳头状瘤是由ＨＰＶ６感染所致。
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| 关 键 词： | 耳肿瘤 外耳道 乳头状瘤 DNA 乳头状瘤病毒 Papilloma of external auditory canal Polymerase chain reaction Papillomaviruses Microscopy electron |
Detection of Human Papilloma Virus DNA in Papilloma of External Auditory Canal |
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| XIA Ming-Ye, ZHU Wen-Yuan, LU Jin-Yu,et al..Detection of Human Papilloma Virus DNA in Papilloma of External Auditory Canal[J].Chinese Journal of Dermatology,1994,27(6):349-350,T002. |
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| Authors: | XIA Ming-Ye ZHU Wen-Yuan LU Jin-Yu |
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| Institution: | XIA Ming-Ye, ZHU Wen-Yuan, LU Jin-Yu, et al. |
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| Abstract: | We examined 15 specimens from 14 patients with papilloma of external auditory canal. Histopathologi- cally, all cases revealed papillomatosis. A few focal vacuoular cells on the upper part of the stratum malpighil were found in 5 cases. Ultrastructually, in the vacuoular cell, the number of perichromatin gran- "ies and inter-chromatin granules and nuclear bodies were increased. No virus granule was present. HPV6 was detected in all specimens by means of polymerase chain reaction. No HPV 8, 11, 16, 18, 31 and 33 were found. These results suggest that papilloma of external auditory canal is caused by HPV6 infection. |
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| Keywords: | Papilloma of external auditory canal Polymerase chain reaction Papillomaviruses Microscopy electron |
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