S100A6在宫颈癌组织中的表达及其意义

目的研究S100A6基因在不同宫颈病变组织中的表达情况,分析其与宫颈癌淋巴结转移的关系。方法应用荧光定量PCR技术定量分析宫颈良性病变13例、宫颈癌未合并淋巴结转移和宫颈癌合并淋巴结转移各25例的宫颈组织中S100A6基因的表达量。结果 S100A6基因在不同病变宫颈组织中均有表达,宫颈癌合并淋巴结转移组中表达最高,宫颈癌未合并淋巴结转移组表达次之,宫颈良性病变组最低。结论 S100A6基因在不同病变宫颈组织中表达均有差异,随着宫颈病变程度及浸润转移表达增高,结合临床可以作为评价宫颈癌转移浸润危险性的参考指标之一。

Expression and Role of S100A6 in Cervical Cancer

Objective To compare the expression of S100A6 gene in different cervical lesion tissues and analyze the relationship between the expression level and the lymph node metastasis of cervical cancer. Methods We analyzed the S100A6 expression level of 13 cases of benign cervical lesions, 25 cases of cervical cancer without lymph node metastasis, 25 cases of cervical cancer with lymph node metastasis by using real-time fluorescence quantitative RT-PCR. Results S100A6 gene showed its expression in different cervical lesion tissues,and the cervical cancer with lymph node metastasis group showed its highest expression level,the next was the cervical cancer without lymph node metastasis group and the lowest was the cervical benign lesion group. Conclusion The expression of S100A6 gene in different cervical lesion tissues is different, and as the degree of cervical lesion, invasion and metastasis increases, its expression increases, which can be used as one of the indicators for the evaluation of the transfer of invasive cervical cancer risk.