| 衰减全反射傅里叶变换红外光谱法定量分析西咪替丁A晶型的含量 |
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| 引用本文： | 张雅军,田颂九. 衰减全反射傅里叶变换红外光谱法定量分析西咪替丁A晶型的含量[J]. 中国药学杂志, 2005, 40(20): 1587-1588 |
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| 作者姓名： | 张雅军 田颂九 |
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| 作者单位： | 中国药品生物制品检定所,北京,100050 |
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| 摘 要： | 目的建立西咪替丁A晶型的含量测定方法。方法采用衰减全反射傅里叶变换红外光谱法定量分析技术测定西咪替丁A晶型的含量。结果西咪替丁吸收度的峰高比与其浓度呈良好的线形关系,相关系数r=0.9991,平均回收率为101.0%,RSD 2.5%。结论本方法操作简便、快速、专属性高、结果满意。
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| 关 键 词： | 衰减全反射傅里叶变换红外光谱法 西咪替丁A晶型 含量测定 |
| 文章编号： | 1001-2494（2005）20-1587-03 |
| 收稿时间： | 2005-01-20 |
| 修稿时间： | 2005-01-20 |
Determination of cimetidine polymorphic form A by ATR-FTIR |
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| ZHANG Ya-jun,TIAN Song-jiu. Determination of cimetidine polymorphic form A by ATR-FTIR[J]. Chinese Pharmaceutical Journal, 2005, 40(20): 1587-1588 |
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| Authors: | ZHANG Ya-jun TIAN Song-jiu |
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| Affiliation: | National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050, China |
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| Abstract: | OBJECTIVE To establish a method for the determination of cimetidine polymorphic form A. METHODS Attenuated Total Reflectance-Fourier transform Infrared spectroscopy(ATR-FTIR) was used to determine the content of cimetidine polymorphic form A. RESULTS There was a good linear relationship between the peak high ratio of absorbance and the cimetidine A concentration(r=0.9991), the average reovery was 101.5%, and relative standard deviation was 2.5%. CONCLUSION This method is simple, fast, specific and the results are satisfactory. |
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| Keywords: | ATR-FTIR cimetidine polymorphic form A content determination |
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