Aldosterone blockade in post-acute myocardial infarction heart failure |
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Authors: | Pitt Bertram Ferrari Roberto Gheorghiade Mihai van Veldhuisen Dirk J Krum Henry McMurray John Lopez-Sendon Jose |
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Affiliation: | University of Michigan Medical Center, William Beaumont Hospital, Cardiovascular Department, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA. bpitt@med.umich.edu |
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Abstract: | Development of heart failure (HF) or left ventricular systolic dysfunction (LVSD) significantly increases mortality post acute myocardial infarction (AMI). Aldosterone contributes to the development and progression of HF post AMI, and major guidelines now recommend aldosterone blockade in this setting. However, lack of practical experience with aldosterone blockade may make clinicians hesitant to use these therapies. This review is based on a consensus cardiology conference that occurred in May 2005 (New York City) concerning these topics. Potential barriers to the use of aldosterone blockade are discussed and an algorithm for appropriate in-hospital pharmacologic management of AMI with LVSD and/or HF is presented. |
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Keywords: | aldosterone myocardial infarction heart failure left ventricular systolic dysfunction eplerenone EPHESUS |
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