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| 抑郁症的神经可塑性机制 | |
| 引用本文： | 徐林. 抑郁症的神经可塑性机制[J]. 中南大学学报(医学版), 2008, 33(4): 326-330 |
| 作者姓名： | 徐林 |
| 作者单位： | 1.中国科学院昆明动物研究所动物模型与人类疾病机制重点实验室， 昆明 650223； 2.中南大学湘雅附二院精神卫生研究所， 长沙 410011 |
| 摘 要： | 以抗抑郁症药物的作用机制反推抑郁症的发病机制存在局限性,而且两者至今并不完全清楚.最近的证据显示基因和早期生活应激事件与抑郁症的发生存在密切关系,最终与神经可塑性的细胞分子机制汇聚.展现了对抑郁症的发生机制和抗抑郁症药物的作用机制的最新理解. |
| 关 键 词： | 抑郁症 神经可塑性 应激 |
| 文章编号： | 1672-7347(2008)04-0326-05 |
| 收稿时间： | 2008-01-02 |
| 修稿时间： | 2008-01-02 |
Neural plasticity mechanism of depression |
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| XU Lin. Neural plasticity mechanism of depression[J]. Journal of Central South University. Medical sciences, 2008, 33(4): 326-330 | |
| Authors: | XU Lin |
| Affiliation: | 1.Key Laboratory of Animal Models and Human Disease Mechanism, Institute of Zoology in Kunming, Chinese Academy of Sciences, Kunming 650223; 2. Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha 410011, China |
| Abstract: | The current hypothesis of depression is limited by back reasoning from the action of antidepressant, because both the pharmacological and pathological mechanisms are not fully understood.Recent evidence shows that genes and early life stress are associated with depression, and the mechanisms are converged on those of neural plasticity. These developments open a new avenue to understand the pathological and pharmacological mechanisms of depression. |
| Keywords: | depression neural plasticity stress |
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