| 剪切应力作用下血小板活化时钙离子浓度的变化 |
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| 引用本文： | 张民花 汪及元 蔡英姬. 剪切应力作用下血小板活化时钙离子浓度的变化[J]. 延边医学院学报, 2005, 28(3): 180-182 |
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| 作者姓名： | 张民花 汪及元 蔡英姬 |
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| 作者单位： | 延边大学医院血液内科，延边大学医院血液内科，延边大学基础医学院人体解剖学与组织胚胎学教研室 吉林延吉133000 |
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| 摘 要： | [目的]探讨剪切应力在血栓性疾病中诱导血小板活化的机制.[方法]采用Fura-2/AM法检测不同剪切应力下的血小板内钙离子浓度,观察其变化.[结果]未受剪切应力作用时血小板内钙离子浓度为(29.88±8.89)nmol/L,在低及高剪切应力作用后钙离子浓度分别上升为(57.32±18.32)nmol/L 及(128.28±56.28)nmol/L,与未受剪切应力作用前相比较均有显著性差异.[结论]剪切应力诱导的血小板聚集与血小板内钙离子浓度的变化有相关性.
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| 关 键 词： | 血小板活化 血栓形成 剪切应力 |
| 文章编号： | 1000-1824(2005)03-0180-03 |
| 收稿时间： | 2005-05-11 |
| 修稿时间： | 2005-05-11 |
Changes of concentration of calcuim ions in platelet activation under shearing stress |
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| ZHANG Min-hua,WANG Ji-yuan,CAI Ying-ji. Changes of concentration of calcuim ions in platelet activation under shearing stress[J]. Journal of Medical Science Yanbian University, 2005, 28(3): 180-182 |
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| Authors: | ZHANG Min-hua WANG Ji-yuan CAI Ying-ji |
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| Abstract: | OBJECTIVE To investigate the mechanism of inducing platelet activation under shearing stress. METHODS The concentration of calcuim ions under the diffical shering stress was dertermineded by Fura-2/AM method, and the changes of that were studied. RESULTS The concentration of calcium ions was (29.88±8.89)nmol/L before being gived the shearing stress, and that was (57.32±18.32)nmol/L under the low shearing stress, and that was (128.28±56.28)nmol/L under high shearing stress. There had significant difference between the concentration of calcium ions between before and after being given shearing stress. CONCLUSION The platelet agglutination inducing by shear stress correlates with the change of concentration of calcuim ions in blood platelet. |
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| Keywords: | platelet activation thrombosis shearing stress |
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