丹参川芎嗪混合液对痴呆样大鼠学习记忆障碍的影响

目的 研究丹参、川芎嗪混合液(DCs)对痴呆样大鼠学习记忆障碍的影响.方法 以三氯化铝和D-半乳糖建立痴呆样大鼠动物模型,以吡拉西坦作阳性对照,观察DCs对痴呆样大鼠学习记忆障碍的影响.结果 与模型组比较,DCs能改善痴呆样大鼠学习记忆能力,可增加大鼠主动反应次数,提高大鼠学习成绩,显著增加大鼠主动回避次数,减少逃避失败次数,被动逃避延迟时间显著缩短.结论 DCs对痴呆样大鼠的学习记忆障碍的有明显改善作用.

Effects of the complexus of radix salviae miltiorrhizae and ligustrazin on the learning and memory ability in Alzheimer disease rats

Objective To study the effect of the complexus of radix salviae miltiorrhizae and lignstrazin (DCs) on the learning and memory impairment in Alzheimer disease rats. Methods Rats were randomly divided in- to 5 groups(10 rats/group):normal eontrol group, Alzheimer disease model group toxified with AlCl3 and D-gal,3 groups toxified with AICl3 and D-gal,whieh were treated with the different drugs including piracetam and DCs1,2. After 80 days,step-through and morris water maze experiments were used to detect the learning and memory ability. Results Compared with Alzheimer disease model group,DCs obviously improved the learing and memory ability of Alzheimer disease rats,it is increased significantly that active reaction, and the number of active avoidance, improve achievement, evasion failed to reduce the number of passive evade significantly shorten the delay time in Des-treated group. Conclusion DCs markedly improved the learing and memory ability of Alzheimer disease rats.