The effect of caffeic acid phenethyl ester on ischemia-reperfusion injury in comparison with alpha-tocopherol in rat kidneys |
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| Authors: | Irmak M K Koltuksuz U Kutlu N O Yağmurca M Ozyurt H Karaman A Akyol O |
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| Affiliation: | (1) Department of Biochemistry, Faculty of Medicine, İnonu University, Malatya, Turkey, TR;(2) Department of Pediatric Surgery, Faculty of Medicine, İnonu University, Malatya, Turkey e-mail: ukoltuksuz@inonu.edu.tr Tel.: +90-422-3113759; Fax: +90-422-3410728, TR;(3) Department of Pediatrics, Faculty of Medicine, İnonu University, Malatya, Turkey, TR;(4) Department of Histology and Embryology, Faculty of Medicine, İnonu University, Malatya, Turkey, TR |
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| Abstract: | Oxygen-derived free radicals have been implicated in the pathogenesis of renal injury after ischemia-reperfusion. Caffeic acid phenethyl ester (CAPE), an active component of propolis extract, exhibits antioxidant and anti-inflammatory properties. To determine whether CAPE offers any advantage over α-tocopherol, we compared their effects on an in vivo model of renal ischemia-reperfusion injury in rats. CAPE at 10 μmol/kg or α-tocopherol at 10 mg/kg was administered intraperitoneally before reperfusion. Acute administration of CAPE suppressed ischemia-reperfusion induced renal lipid peroxidation and tissue injury more than α-tocopherol. CAPE may therefore offer a therapeutic advantage in acute injury settings. Received: 9 October 2000 / Accepted: 23 February 2001 |
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| Keywords: | Reperfusion injury Kidney Caffeic acid phenethyl ester α -Tocopherol |
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