基质金属蛋白酶抑制剂RECK对子宫内膜异位症中微血管密度的影响及意义

目的:研究正常子宫内膜及异位子宫内膜组织中RECK蛋白表达及微血管密度(MVD),探讨RECK蛋白对MVD的影响及在子宫内膜异位症发生发展中的作用。方法:应用免疫组化S-P法检测48例异位内膜组织标本,31例正常内膜中微血管密度(MVD)及RECK蛋白的表达情况。结果:RECK蛋白在异位内膜中阳性表达率为43.8%,正常子宫内膜中阳性表达率为87.1%,两组比较有显著差异(P<0.05)。MVD计数在异位内膜表达为17.55±4.82,在正常内膜中为8.79±2.45,两组比较有显著差异(P<0.05)。RECK的表达与MVD呈负相关(r=-0.530,P<0.05)。结论:RECK蛋白的低表达与EMs的新生血管生成有关,在EMs发生发展中起重要作用。

The effect and significace of the matrix metalloproteinase inhibitor RECK on microvessel density in endometriosis

Objective:To investigate microvessel density(MVD) and the matrix metalloproteinase inhibitor RECK expression in the ectopic endometrium and eutopic endometrium,explore the effect and significace of the matrix metalloproteinase inhibitor RECK on MVD in the occurrence and development of endometriosis.Methods:The expression of MVD and RECK in the ctopic endometrium from 48 patients with endometriosis and the eutopic endometrium from 31 patients without endometriosis were detected by immunohistochemical analysis.Results:The expression of RECK in eutopic endometrium(87.1%) was higher than that in ctopic endometrium(43.8%)(P<0.05).MVD in ctopic endometrium(17.55±4.82) was higher than that in eutopic endometrium(8.79±2.45)(P<0.05).MVD was negatively related to the expression of RECK(γ=-0.530,P<0.05).Conclusion:The low expression of RECK may play an important role in the course of the growth of endometriosis.