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| 趋化细胞因子ENA-78在子宫腺肌病中的表达 | |
| 引用本文： | 徐红,陈煜岊,何中慧,梁秀就,徐文生,蒙玉刚.趋化细胞因子ENA-78在子宫腺肌病中的表达[J].中国妇幼保健,2009,24(13). |
| 作者姓名： | 徐红 陈煜岊 何中慧 梁秀就 徐文生 蒙玉刚 |
| 作者单位： | 1. 广西医科大学第一附属医院妇科,广西,南宁,530021 2. 柳州市人民医院工作 3. 广西医科大学第一附属医院病理科 |
| 基金项目： | 广西自治区科学基金，广西医疗卫生科研课题 |
| 摘 要： | 目的:探讨趋化细胞因子(ENA-78)在子宫腺肌病组织中的表达及其与子宫腺肌病发生、发展的关系。方法:收集27例子宫腺肌病患者的异位内膜及在位内膜组织和18例子宫肌瘤在位子宫内膜组织(对照组),分别测定ENA-78的表达。结果:①ENA-78阳性染色定位于腺体细胞胞浆内;②子宫腺肌病患者的在位内膜及异位内膜ENA-78的表达高于对照组(P<0.05);③不同月经周期中子宫腺肌病患者的在位内膜与异位内膜组织中ENA-78的表达无统计学意义(P>0.05)。结论:ENA-78在子宫腺肌病的异位内膜及在位内膜组织中表达增强,提示ENA-78在子宫腺肌病发生、发展中有一定意义。 |
| 关 键 词： | 趋化细胞因子 ENA-78 子宫腺肌病 免疫组织化学 |
Expression of chemokine epithelial neutrophil -activating peptide -78 in adenomyosis |
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| Abstract: | Objective:To explore the expression of epithelial neutrophil-activating peptide-78(ENA-78) in adenomyosis and the relationship between ENA-78 and the mechanism of ademomyosis.Methods:The expression of ENA-78 in the ectopic and eutopic endometria of 27 patients with adenomyosis and in the eutopic endometria of 18 patients with hysteromyoma were detected by immunohistochemistry.Results:①ENA-78 located in the cytoplasma of epithelial glands.②The expression levels of ENA-78 in the ectopic and eutopic endometria in adenomyosis group were significantly higher than those in control group(P<0.05).③The expression of ENA-78 in the ectopic and eutopic endometria of adenomyosis had no difference between secretory phase and proliferative phase(P>0.05).Conclusion:The expression of ENA-78 in the ectopic and eutopic endometria of adenomyosis increases,which suggests that ENA-78 may play a role in pathophysiology and progression of adenomyosis. |
| Keywords: | Chemokines Epithelial neutrophil-activating peptide-78 Adenomyosis Immunohistochemistry |
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