Insulin resistance and glomerular hemodynamics in essential hypertension |
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Authors: | Andronico Giuseppe Ferraro-Mortellaro Rosella Mangano Maria T Romé Maria Raspanti Francesco Pinto Antonio Licata Giuseppe Seddio Giovanna Mulé Giuseppe Cerasola Giovanni |
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Affiliation: | Dipartimento di Medicina Interna, Malattie Cardiovascolari e Nefrourologiche, Università degli Studi di Palermo, via Lenin Mancuso 15, 90129 Palermo, Italy. androp@unipa.it |
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Abstract: | BACKGROUND: Arterial hypertension is an important cause of end-stage renal failure. Insulin has been shown to modify glomerular hemodynamics in hypertensive subjects. The aim of this work, therefore, was to observe the relationships between renal hemodynamics and insulin resistance in arterial hypertension. METHODS: Sixty-two non-diabetic hypertensive patients and 25 healthy normal subjects were studied. Renal plasma flow and the glomerular filtration fraction were determined by renoscintigraphy and the insulin sensitivity by an oral glucose test. RESULTS: Renal plasma flow in hypertensive subjects was lower than expected and was related to pressure values, whereas the mean glomerular filtration rates were not different in the two groups. In most patients the filtration fraction was higher than expected. A lower glomerular filtration rate and lower filtration fraction were found in patients with higher insulin resistance. CONCLUSIONS: The progressive decrease of glomerular function in subjects with hypertension is linked with insulin-resistance. |
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