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Psychosocial Correlates of Atrial Natriuretic Peptide: A Marker of Vascular Health |
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| Authors: | Patrick Smith Ph.D. Martti T. Tuomisto Ph.D. James Blumenthal Ph.D. Andrew Sherwood Ph.D. Lauri Parkkinen MS Mika Kähönen MD Ilkka Pörsti MD Silja Majahalme MD Väinö Turjanmaa MD |
| Affiliation: | 1. Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA 2. School of Social Sciences and Humanities (Psychology), University of Tampere, Tampere, Finland 3. Department of Psychiatry, Tampere University Hospital, Tampere, Finland 4. School of Medicine, University of Tampere, Tampere, Finland 5. Tampere University Hospital, Tampere, Finland 6. Appleton Cardiology Thedacare, Appleton, WI, USA |
| Abstract: | BackgroundPsychosocial factors have been associated with cardiovascular outcomes, but few studies have examined the association between psychosocial function and natriuretic peptides.PurposeThe purpose of this study is to determine the predictive value of hostility, anger, and social support in relation to atrial natriuretic peptide (ANP), a marker of vascular health, among middle-aged men.MethodsOne hundred twenty-one men (mean age?=?39.8 years, SD?=?4.1) underwent assessments of ANP and completed the Cook–Medley Hostility Scale, the Spielberger State–Trait Anger Scale, and the Interview Schedule for Social Interaction.ResultsHigher levels of hostility (β?=?0.22 [95 % CI 0.04, 0.40], P?=?0.032) and trait anger (β?=?0.18 [95 % CI 0.01, 0.37], P?=?0.044) were associated with greater ANP levels. In contrast, higher perceived social support was also associated with lower ANP levels, (β?=??0.19 [95 % CI ?0.05, ?0.41], P?=?0.010).ConclusionsPsychosocial factors, including hostility, anger, and social support, are associated with varying ANP levels among middle-aged men, independent of cardiovascular and behavioral risk factors. |
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