| 咪唑啉受体与抑郁症 |
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| 引用本文： | 殷为勇,郑荣远.咪唑啉受体与抑郁症[J].中国临床神经科学,2006,14(3):318-321. |
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| 作者姓名： | 殷为勇 郑荣远 |
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| 作者单位： | 温州医学院附属一院神经内科,325000 |
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| 摘 要： | 抑郁症患者血小板和中枢神经系统的咪唑啉受体(IR)的I1R及I2R亚型与正常人比较有着特定的改变。而且IR内源性配体胍丁胺和一些I2R的配体有一定的抗抑郁作用。IR可能是通过调节单胺类递质和单胺氧化酶,参与抑郁症的发病过程。
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| 关 键 词： | 咪唑啉受体 抑郁症 胍丁胺 |
| 文章编号： | 1008-0678(2006)03-0318-04 |
| 修稿时间： | 2005年6月27日 |
Relevance of Imidazoline Receptors to Depression |
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| YIN Wei-Yong,ZHENG Rong-Yuan.Relevance of Imidazoline Receptors to Depression[J].Chinese Journal of Clinical Neurosciences,2006,14(3):318-321. |
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| Authors: | YIN Wei-Yong ZHENG Rong-Yuan |
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| Abstract: | Imidazoline receptors(IR), including I1 and I2 receptors,have been found to be altered in depressed patients compared with control subjects. The endogenous neurotransmitter agmatine and other I2 selective compounds have been reported to exhibit antidepressant properties. The antidepressant-like effects of IR agents may be related to inhibition of MAO and alterations of central monoaminergic activity. |
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| Keywords: | imidazoline receptors depression agmatine |
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