| 胃印戒细胞癌组织中p53和HER-2表达及其临床意义 |
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| 引用本文： | 刘月仙,丁永斌,夏建国,梁辉,张殿彩,孙玲.胃印戒细胞癌组织中p53和HER-2表达及其临床意义[J].江苏医药,2012(1):63-65,125. |
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| 作者姓名： | 刘月仙 丁永斌 夏建国 梁辉 张殿彩 孙玲 |
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| 作者单位： | 南京中医药大学护理学院;南京医科大学第一附属医院普通外科 |
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| 摘 要： | 目的研究p53和HER-2在胃印戒细胞癌中的表达及其临床意义。方法用免疫组化方法分析60例胃印戒细胞癌p53和HER-2的表达及其与临床病理的关系。结果 p53和HER-2蛋白在胃印戒细胞癌中的表达率分别为48.33%(29/60)和23.33%(14/60)。p53和HER-2的表达与肿瘤大小、浸润深度、淋巴结转移相关(P<0.05),而与年龄、肿瘤部位无相关(P>0.05)。结论 p53和HER-2蛋白表达可能与胃印戒细胞的生长及淋巴结转移相关。
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| 关 键 词： | 印戒细胞癌 p53 HER-2 |
Expression and clinical significance of p53 and Her2 in gastric signet cell carcinoma |
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| Institution: | LIU Yuexian,DING Yongbin,XIA Jianguo,et al. Nursing School,Nanjing University of Traditional Chinese Medicine,Nanjing 210029, CHINA |
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| Abstract: | Objective To study the expressions of p53 and HER-2 in gastric signet cell carcinoma. Methods The expressions of p53 and HER-2 were detected in 60 cases with gastric signet cell carcinoma.The relation between the expressions of p53 and HER-2 and clinical pathological charactistics were analyzed as well. Results The positive expression rates of p53 and HER-2 were 48.33%(29/60) and 23.33%(14/60) respectively.The expressions of p53 and HER-2 were correlated to the size,invantion and lymph node metastasis of the tumor(P<0.05),but not associated to age of patients and tumor location(P>0.05). Conclusion The expressions of p53 and HER-2 may facilitate the growth and lymph node metastasis of gastric signet cell carcinoma. |
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| Keywords: | Signet cell carcinoma p53 HER-2 |
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