珠海市鼻咽癌放疗后5年生存随访报告

 【目的】通过随访珠海市2003年3月－2005年3月接受根治性放疗的鼻咽癌患者，计算5年生存率和5年无局部复发率（FLF)和无远处转移生存率（FDM），评价珠海市鼻咽癌的治疗的临床疗效。【方法】随访满5年患者154例， UICC／AJCC 2002分期Ⅰ、Ⅱ、Ⅲ和Ⅳ期分别为12、40、82和20例，随访60～84个月，接受根治性放疗后的5年随访资料纳入研究, 以生存率、无鼻咽局部复发生存率和FDM为预后指标, 通过Cox比例风险模型,分析比较影响鼻咽癌生存、局部复发和远处转移的因素。【结果】5年随访生存率：第1年98%，第3年88% ，第5年79%；5年无局部复发生存率为85.1%；5年FDM为88.31%。全组患者远期放疗不良反应均不明显。根据现有数据的Cox多因素分析提示，临床分期的早晚仍然是影响5年生存率最明显的因素。【结论】珠海市2003年3月－2005年3月收治的鼻咽同期化放疗后患者，在生存率、无局部复发生存率、FDM以及在远期副反应的控制方面，均达到先进水平。

5 Years Survival Follow-up of 154 Cases of Nasopharyngeal Carcinoma in Zhuhai

【Objective】 Through following up patients of nasopharyngeal carcinoma(NPC) who received radical radiotherapy from March 2003 to March 2005,calculate 5-year survival rate,free from local-regional failure survival rate(FLF) and free from distant metastasis survival rate(FDM),and evaluate the clinical efficacy of the treatment of nasopharyngeal carcinoma in Zhuhai City.Methods: 【Methods】 A total of 154 patients were followed up for 5 years.The patients of UICC/AJCC2002 stage Ⅰ,Ⅱ,Ⅲ,and Ⅳ were 12,40,82,and 20,respectively,and were followed up for 60-84 months after radical radiotherapy.The follow-up data of 5-year survival,FLF,and FDM were included in the study;and the factors of NPC survival,recurrence and distant metastasis were analyzed by Cox proportional hazards model.【Results】 The 5-year follow-up survival rates were 98% in the 1st year,88% in the 3rd year,79% in the 5th year.5-year FLF was 85.1% and 5-year FDM was 88.31%,respectively.All the long-term side effects after radiotherapy were not obvious.By Cox multivariate analysis,the data illustrated that clinical stage was still the most conspicuous factor affecting the 5-year survival rate.【Conclusion】 It was well controlled that the survival rate,FLF,FDM and long-term side effects after radiotherapy of the NPC patients from Zhuhai City who received radiotherapy and concurrent chemoradiotherapy from March 2003 to March 2005.