长托宁和阿托品治疗有机磷中毒的临床疗效对比研究

目的：探讨长托宁取代阿托品成为抢救有机磷中毒首选药物的可能性。方法：在广东省8家医院展开了前瞻性、多中心、随机、对照研究,比较长托宁和阿托品治疗有机磷中毒的疗效及不良反应。结果：8家医院共180例患者入选,与阿托品组比较,长托宁组患者的用药次数、住院天数显著减少（P〈0.01）;两组有效率分别为89%和90.1%,两者比较,差异无统计学意义（P〉0.05）;同一患者治疗前后的心率比较,长托宁组差异无统计学意义（P〉0.05）,阿托品组差异有统计学意义（P〈0.01）。结论：长托宁优于阿托品,可成为抢救有机磷中毒的首选药物。

Penehyclidine hydrochloride and atropine on organophosphorus poisoning:Results of multicenter,prospective,comparative study

Objective To study the possibility of penehyclidine hydrochloride instead of atropine to be the first choice used in organophosphorus poisoning treatment.Method A multicenter,prospective,comparative clinical research between penehyclidine hydrochloride and atropine on organophosphorus poisoning was made in 8 hospitals,and the effects and adverse effects were compared between the two drugs.Results Total 180 patients with organophosphorus poisoning were randomly divided into 2 groups:Penehyclidine hydrochloride group(n=90) and atropine group(n=90).The times of administrating drugs and the course of hospitalization in penehyclidine hydrochloride group were less than atropine group(P<0.01).Both penehyclidine hydrochloride and atropine had positive effect on organophosphorus poisoning.Penehyclidine hydrochloride used conveniently and didn′t affect HR(P>0.05),while atropine used inconveniently and affected HR(P<0.01).Conclusion Penehyclidine hydrochloride is much better than atropine in the treatment of organophosphorus poisoning and can be the first choice.