2型糖尿病视网膜病变的相关因素分析

目的探讨2型糖尿病患者糖尿病视网膜病变(DR)的相关危险因素。方法测定225例2型糖尿病患者糖化血红蛋白(HbA1c)、血糖、血压、血脂、尿微量白蛋白(UAER)等各项生化指标并检测眼底,根据眼底病变程度将患者分为糖尿病无视网膜病变组(NDR)、背景期视网膜病变组(NPDR)及增殖期视网膜病变组(PDR),比较各组糖尿病病程、HbA1c、血糖、血压、血脂及UAER与DR的关系。结果NDR组150例(66.7%),NPDR组63例(28.0%),PDR组12例(5.3%);单因素分析显示年龄、病程、UAER、SBP和DBP在3组中差异有显著性(P<0.05),而在HbA1c、BMI、FPG、FINS、TG、TC、LDL-C和Homa-IR差异无显著性(P>0.05);Logistic回归显示病程、UAER、DBP是DR的独立危险因素。结论糖尿病病程、UAER、DBP与DR密切相关,是DR的独立危险因素。

Risk factors analysis of diabetic retinopathy in type 2 diabetes patients

Objective] To investigate the risk factors of diabetic retinopathy (DR) in type 2 diabetes patients. Methods] HbA1c, FPG, BP, lipid, UAER, and other clinical characteristics were tested in 225 Type 2 diabetes patients. All diabetes patients were divided into three groups: non-diabetic retinopathy (NDR), minimal non-proliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR) in according to the examination of fundus. Results] 1. There were 150(66.7%) NDR patients, 63(28.0%) NPDR patients and 12(5.3%) PDR patients. 2. Single factor analysis showed that age, diabetic duration, UAER, SBP and DBP had statistically different in tree groups. 3. Multinomial Logistic Regression analysis showed that diabetic duration, UAER and DBP were independent risk factors for diabetic retinopathy. Conclusion] Diabetic duration, UAER and DBP were three independent risk factors for diabetic retinopathy in type 2 diabetes.