格列美脲与二甲双胍对2型糖尿病胰岛素抵抗的影响

目的 探讨格列美脲、二甲双胍对2型糖尿病（T2DM）患者胰岛素抵抗（IR）的影响。方法 151例T2DM患者分别接受格列美脲、二甲双胍及二药合用治疗，比较三组治疗1年前后的胰岛素抵抗指数（HOMA-IR）的变化。结果 治疗后三组的空腹胰岛素（FINS）水平均较治疗前下降（P〈0．05），且格列美脲组下降的幅度较大（P〈0．05）；治疗后三组的HOMA-IR均较治疗前下降（P〈0．001），但三组间治疗前后的变化无差异（P〉0．05）。结论 格列美脲与二甲双胍均可有效改善T2DM患者的HOMA-IR，与二甲双胍相比格列美脲在减轻高胰岛素血症方面作用更好。

Effect of glimepiride and metformine on insulin resistance in type 2 diabetics

Objective] To investgate the effect of glimepiride and metformine on insulin resistance in patients with type 2 diabetes mellitus. Methods] The levels of HOMA-IR were compared between glimepiride group and metformine group as well as their combination treatment group before and after one year treatment. Results] The levels of fast insulin after one year treatment was higher than before in three groups, But glimepiride group difference was more significant than metformine group and combination group. The levels of HOMA-IR in three groups after one year was lower than before, but there were no significant differences in three groups. Conclusion] Glimepiride and mefformine all improve Homa-IR in patients with type 2 diabetics, but glimepiride is better than metformine in treating hyperinsulina.