Impact of estrogen receptor gene polymorphisms and mRNA levels on obesity and lipolysis – a cohort study |
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| Authors: | Maria Nilsson Ingrid Dahlman Hong Jiao Jan-Åke Gustafsson Peter Arner Karin Dahlman-Wright |
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| Affiliation: | (1) Departments of Biosciences and Nutrition, Karolinska Institutet, S-141 57 Huddinge, Sweden;(2) Department of Medicine at Huddinge, Karolinska Institutet, S-141 86 Stockholm, Sweden |
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| Abstract: | Background The estrogen receptors α and β (ESR1, ESR2) have been implicated in adiposity, lipid metabolism and feeding behaviour. In this report we analyse ESR1 and ESR2 gene single nucleotide polymorphisms (SNPs) for association with obesity. We also relate adipose tissue ESR1 mRNA levels and ESR1 SNPs to adipocyte lipolysis and lipogenesis phenotypes. |
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