^99mTc-HL91与^99mTc-MIBI在鼻咽癌显像中的对比研究

[目的]对比鼻咽癌^99mTc—HL91与^99mTc-MIBI显像的差异。[方法]对24例鼻咽癌患者面罩固定．用GE配置2．5mA X-线球管Hawkeye SPECT分别进行^99mTc-HL91与^99mTc-MIBI断层显像，观察鼻咽肿瘤以及转移淋巴结对HL91和MIBI的摄取情况并计算肿瘤与后颈肌肉摄取比值，采用卡方检验比较两者在显示鼻咽肿瘤和转移淋巴结方面的差异，采用t检验比较两者肿瘤与后颈肌肉摄取比值的差异。[结果]24例鼻咽肿瘤HL91显像均显示，而MIBI仅显示20例（x^2=4．36，P=0．037）。15例有淋巴结转移的患者中．HL91显示14例，MIBI仅显示10例（x^2=3．33．P=0．068）。鼻咽肿瘤与后颈肌肉摄取HL91和MIBI的比值分别为2．25±0．54，2．02±0．81（t=3．46，P=0．001）；而淋巴结转移病灶分别为2．44±0．30，1．92±0．69（t=2．62，P=0．029）。T1-2与T3-4期肿瘤与后颈肌肉摄取HL91以及MIBI的比值均无统计学差异；N1和N2-3期淋巴结与后颈肌肉摄取HL91以及MIBI的比值也无统计学差异。[结论]^99mTc—HL91显像显示鼻咽肿瘤的价值优于^99mTc-MIBI。T分期和N分期不影响肿瘤摄取HL91和MIBI。

Comparison of 99mTc-HL91 and 99mTc-MIBI Imaging in Nasopharyngeal Carcinoma

[Purpose] To compare the difference between imagings by Tc-99m-HL91 and Tc-99m- MIBI in nasopharyngeal carcinoma（NPC）. [Methods] Twenty-four cases with NPC were immobilized with thermoplastic mask and underwent GE Hawkeye SPECT with 2.SmA X-ray after injection of Tc-99m-HL91 on Tc-99m-MIBI. Uptake of MIBI and HL91 by the primary tumor and metastatic nodes was assessed. Then tumor/collare muscle uptake ratio was calculated. Chi square test was used to compare the detection rate of both the primary tumor and metastatic node by the two radioactive tracers. And t test was used to compare the tumor/collare muscle uptake ratio. [Results ] Twenty-four cases with primary tumor were detected by HL91, while only 20 cases were detected by MIBI （x^2=4.36,P=0.037）. Of the 15 patients with nodal metastases, 14 were detected by HL91, and 10 were detected by MIBI （x^2=3.33,P=0.068）. The mean primary tumor/collare muscle uptake ratio was 2.25±0.54 for HL91, and 2.02±0.81 for MIBI （t=3.46,P=0.001）. The mean involved node/muscle uptake ratio was 2.44±0.30 and 1.92±0.69 for HL91 and MIBI, respectively（t=2.62, P=0.029）. No statistical difference of HL91 uptake ratio was found between T1-2 and T3-4 disease or between N1 and N2-3 disease. Nor was MIBI uptake ratio. [Conclusions] ^99mTc-HL91 is better than ^99mTc-MIBI in detecting nasopharyngeal carcinoma. Neither HLgl nor MIBI uptake is affected by T staging or N staging.