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Nitrofurantoin damages DNA of human cells |
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| Authors: | M. Hirsch-Kauffmann Prof. Dr. P. Herrlich M. Schweiger |
| Affiliation: | (1) Max-Planck-Institut für Zellbiologie, Wilhelmshaven;(2) Max-Planck-Institut für Molekulare Genetik, Berlin-Dahlem;(3) Institut für Biochemie der Universität, Innsbruck;(4) Institut für Genetik der Universität und Institut für Genetik und Toxikologie der, Spaltstoffe, Pf. 3640, D-7500 Karlsruhe 1, Federal Republic-Germany |
| Abstract: | Summary Nitrofurantoin causes damage to DNA of cultured diploid human fibroblasts. As a consequence DNA synthesis is blocked. The damage is removed by the normal enzymatic DNA repair system. Xeroderma pigmentosum fibroblasts which are defective in the excision endonuclease fail to repair nitrofurantoin-caused lesions. |
| Keywords: | Nitrofurantoin mechanism of antibacterial action Drug side effects Diploid human fibroblasts DNA repair Xeroderma pigmentosum |
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