| 全血细胞组织因子活性改变在血栓前状态中的意义 |
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| 引用本文： | 徐吟亚,刘金花. 全血细胞组织因子活性改变在血栓前状态中的意义[J]. 血栓与止血学, 2010, 16(2): 63-65 |
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| 作者姓名： | 徐吟亚 刘金花 |
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| 作者单位： | 武钢总医院检验科,武汉,430080 |
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| 摘 要： | 目的检测血循环中血细胞组织因子促凝活性(tissue factor procoagulant activity,TF-PCA),观察有疑似弥散性血管内凝血(disseminated intravascular coagulation,DIC)、疑似深部静脉血栓形成(deep vein thrombosis,DVT)以及糖尿病(diabetes mellitus,DM)时,TF-PCA的改变及其在判断血栓前状态中的意义。方法受检病例95例(其中疑似DIC组12例,疑似DVT组36例,DM组47例)为我院近期住院和门诊患者,正常对照组38例为体检正常自愿献血者。采用脂多糖(lipopolysaccharide,LPS)刺激的全血复钙时间检测全血细胞TF活性(tissue factor clotting time,TiFaCT),根据全血凝固时间缩短的程度(△s)来判断TF-PCA的强弱,对其检测结果进行统计学分析。结果疑似DIC组、疑似DVT组及DM患者组TF-PCA分别是(85.8±16.9)△s、(69.8±17.5)△s、(67.1±21.4)△s,与正常组(30.4±25.1)△s比较差异有极显著性(P0.01)。结论疑似DIC患者、疑似DVT患者和DM患者在LPS刺激后TF-PCA明显增强,TiFaCT对于血栓前状态的诊断及预后评价有重要临床参考价值。
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| 关 键 词： | 组织因子促凝活性 血栓前状态 弥散性血管内凝血 深部静脉血栓形成 糖尿病 |
Significance of Measuring Whole Blood Tissue Factor in Prothrombotic State |
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| XU Yin-ya,LIU Jin-hua. Significance of Measuring Whole Blood Tissue Factor in Prothrombotic State[J]. Chinese Journal of Thrombosis and Hemostasis, 2010, 16(2): 63-65 |
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| Authors: | XU Yin-ya LIU Jin-hua |
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| Affiliation: | XU Yin-ya,LIU Jin-hua(Department of Clinical laboratory,General Hospital of Wuhan Iron , Steel Company,Wuhan,430080,China) |
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| Abstract: | Objective To observe the changes of TF-PCA in patients suspected with DIC or DVT and diabetic,and evaluate the significance of TF-PCA to the diagnosis of the prombotic state.Methods 95 samples were taken from hospitalized patients and out-patients(12 cases of suspected with DIC,36 cases of suspected with DVT,and 47 cases of diabetes mellitus),with 38 samples taken from examined people set as normal control.Recalcification time of LPS-stimulated whole blood was applied to evaluate tissue factor clotting time... |
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| Keywords: | Tissue factor procoagulant activity Prothrombotic state Deep vein thrombosis Diabetes mellitus |
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