| 维生素D受体FOK1基因多态性与蒙古族2型糖尿病视网膜病变关联性分析 |
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| 引用本文： | 乌云娜,张雨平,王爱萍. 维生素D受体FOK1基因多态性与蒙古族2型糖尿病视网膜病变关联性分析[J]. 内蒙古医学杂志, 2010, 42(3): 271-274 |
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| 作者姓名： | 乌云娜 张雨平 王爱萍 |
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| 作者单位： | 1. 呼和浩特市第一医院检验科,内蒙古,呼和浩特,010010
2. 呼和浩特市卫生局办公室,内蒙古,呼和浩特,010010 |
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| 摘 要： | 目的：研究维生素D受体基因多态性在中国蒙古族人群中的分布情况,并探讨维生素D受体Fok1基因多态性与蒙古族2型糖尿病视网膜病变的相关性。方法：采用聚合酶链-限制性片断长度多态性检测方法,比较蒙古族正常人群和2型糖尿病视网膜病变患者之间维生素D受体基因多态性等位基因频率和基因型频率的差异。结果：维生素D受体基因Fok1酶切位点各基因型在2型糖尿病视网膜病变组和正常对照组中的分布差异具有统计学意义。两组间等位基因频率总体分布差异有统计学意义。2型糖尿病视网膜病变组等位基因f和基因型ff频率明显高于正常对照组。结论：中国蒙古族人群中维生素D受体基因多态性与2型糖尿病视网膜病变相关联,等位基因f是蒙古族2型糖尿病视网膜病变的易感基因。
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| 关 键 词： | 糖尿病视网膜病变 维生素D受体 基因多态性 |
Association Between DNA Polymorphism of Human Vitamin D Receptor(VDR)Gene and Type 2 Diabetic Retinopathy in Mongolian People |
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| WU Yun-na,ZHANG Yu-ping,WANG Ai-ping. Association Between DNA Polymorphism of Human Vitamin D Receptor(VDR)Gene and Type 2 Diabetic Retinopathy in Mongolian People[J]. Inner Mongolia Medical Journal, 2010, 42(3): 271-274 |
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| Authors: | WU Yun-na ZHANG Yu-ping WANG Ai-ping |
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| Affiliation: | 1.Department of Clinicallaboratory/a>;The First hospital of Huhhot City/a>;Huhhot 010010 China/a>;2.Huhhot City Aealth Bureau/a>;Huhhot 010010 China |
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| Abstract: | Objective:To explore the relationship between DNA polymorphism of human vitamin D receptor(VDR) gene and type 2 diabetic retinopathy in mongolian people.Method:By restriction fragment length polymorphism analysis,the alleles frequencies and genotype frequencies of VDR gene were compared with normal subjects and type 2 diabetic retinopathy in mongolian people.Results: The prevalence of VDR gene genotype frequencies and alleles frequencies in type 2 diabetic retinopathy were significantly different with that ... |
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| Keywords: | Diabetic retinopathy Vitamin D receptor Gene polymorphism |
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