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MR1-restricted mucosal associated invariant T (MAIT) cells in the immune response to Mycobacterium tuberculosis |
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| Authors: | Marielle C. Gold Ruth J. Napier David M. Lewinsohn |
| Affiliation: | 1. Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, OR, USA VA Portland Health Care System (VAPORHCS), Portland, OR, USA Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA Correspondence to: Marielle C. Gold Oregon Health and Science University Pulmonary and Critical Care Medicine 3181 SW Sam Jackson Park Road Mail code VA R&D 11 Portland, OR 97239, USA Tel.: +1 503 220 3428 e-mail: goldm@ohsu.edu;2. Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, OR, USA;3. Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, OR, USA VA Portland Health Care System (VAPORHCS), Portland, OR, USA Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA |
| Abstract: | The intracellular pathogen Mycobacterium tuberculosis (Mtb) and its human host have long co-evolved. Although the host cellular immune response is critical to the control of the bacterium information on the specific contribution of different immune cell subsets in humans is incomplete. Mucosal associated invariant T (MAIT) cells are a prevalent and unique T-cell population in humans with the capacity to detect intracellular infection with bacteria including Mtb. MAIT cells detect bacterially derived metabolites presented by the evolutionarily conserved major histocompatibility complex-like molecule MR1. Here, we review recent advances in our understanding of this T-cell subset and address the potential roles for MR1-restricted T cells in the control, diagnosis, and therapy of tuberculosis. |
| Keywords: | MR1 mucosal associated invariant T cells (MAIT) tuberculosis |