| 创伤应激相关精神行为异常与中枢神经细胞游离钙改变 |
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| 引用本文： | 张汝,王庆松,李燕,丁盛,黄大熔.创伤应激相关精神行为异常与中枢神经细胞游离钙改变[J].西南国防医药,2002,12(3):195-198. |
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| 作者姓名： | 张汝 王庆松 李燕 丁盛 黄大熔 |
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| 作者单位： | 1. 成都军区总医院,成都,610083
2. 成都军区机关第一门诊部,成都,610011 |
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| 基金项目： | 国家自然科学基金 (NO :39870 2 84)，全军“九·五”医药卫生科研基金 (NO :98M0 4 4 )资助。 |
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| 摘 要： | 目的：观察创伤应激相关精神、行为异常与中枢神经细胞游离钙改变的关系。方法：在建立大鼠海马惊厥阈下电刺激创伤后应激障碍模型的基础上，采用Fura2／AM荧光标记技术，动态检测了大鼠海马、额叶皮层神经细胞内游离Ca^2 含量变化。结果：海马神经细胞内游离钙浓度于电刺激停止后12h明显升高，24h达高峰，1w时基本恢复；而额叶皮层只出现了短暂的细胞内钙浓度增高。结论：海马神经细胞Ca^2 调控异常可能是创伤应激相关精神、行为障碍的一个重要病理生理基础。
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| 关 键 词： | 创伤 应激相关精神行为异常 中枢神经细胞游离钙 海马 |
| 修稿时间： | 2001年5月26日 |
RELATIONSHIP BETWEEN ALTERATION OF INTRACELLULAR FREE CALCIUM IN CENTRAL NERVOUS SYSTEM AND TRAUMA-RELATED BEHAVIOR DISORDERS IN RATS |
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| Zhang Ru,Wang Qingsong,Li Yan,Ding Sheng,Huang Darong General Hospital of Chengdu Military Command,Chengdu,First Office Clinic of Chengdu Military Command,Chengdu.RELATIONSHIP BETWEEN ALTERATION OF INTRACELLULAR FREE CALCIUM IN CENTRAL NERVOUS SYSTEM AND TRAUMA-RELATED BEHAVIOR DISORDERS IN RATS[J].Medical Journal of National Defending forces in Southwest China,2002,12(3):195-198. |
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| Authors: | Zhang Ru Wang Qingsong Li Yan Ding Sheng Huang Darong General Hospital of Chengdu Military Command Chengdu First Office Clinic of Chengdu Military Command Chengdu |
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| Institution: | Zhang Ru,Wang Qingsong,Li Yan*,Ding Sheng,Huang Darong General Hospital of Chengdu Military Command,Chengdu,610083,*First Office Clinic of Chengdu Military Command,Chengdu,610011 |
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| Abstract: | Objective: To study the relationship between trauma-related behavior disorder and intracellular free calcium alteration in central nervous system. Method: A stable and satisfied model of post-traumatic stress disorder was established and then the level of intracellular free calcium in rats' hippocampus and frontal cortex tissues was detected by Fura-2/AM. Result: It was showed that the level of intracellular free calcium in hippocampus increased significantly at 12 h after the last stimulation, and reached to the highest point at 24 h, but that in the frontal cortex increased temporally. Conclusion: It is suggested that the abnormality of calcium regulation in hippocampus after trauma plays an important role in trauma-related behavior disorder. |
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| Keywords: | behavior disorder stress trauma hippocampus |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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