结核分枝杆菌耐多药情况分析

目的：评估上海市近年来耐多药结核病（MDR—TB）发生情况。方法：对本市2749株结核分枝杆菌耐药性测定结果进行分析。结果：共查出234株耐多药菌株，其中新发病。组156株（6．8％），复治病人组35株（18．9％），外地病人组43株（15．8％）。234株耐多药菌株中，耐2药133株（56．8％），耐3药66株（28．2％），耐4药35株（15．0％）。耐2药菌株中，以HR耐药为主，占27．8％。耐3药菌株中，以HRS耐药为主，占66．7％。复治病人和外地病人组的耐多药率显著高于新发病人组，P＜0．01。结论：必须加强对复治病人和外地病人的管理和治疗。

Analysis on the multi- drug resistance in strains of Mycobacterium tuberculosis

To evaluate the situation of multidrug- resistant tuberculosis in Shanghai. Methods:The multidrug- resistance in 2749 strains of M. tuberculosis was analysed. Results: There were 234 of multidrug - resistance in all of 2749 strains, among which 156(6. 8 % ) were from new patients, 35 (18. 9 % ) fromretreatment patients, and 43 (15. 8 % ) from nonlocal patients. The drug - resistance strains to two agentswere 133 (56. 8 % ), to three 66(28. 2 % ), and to four 35 (15. 0 % ) respectively in all of the 234 strains. Thedrug - resistance to INH and RFP was main stranis in drug - resistance to two agents. It was most strain thatrests to INH, RFP and SM simultaneously in the strains resistant to three agents. The multidrug- resistantrate in retreatment and nonlocal patients was significantly higher than that of the new patients(P< 0. 01 ).Conclusion: The management and treatment must be strengthen for retreatment and nonlocal patient groups.