后肢梗阻性淋巴水肿动物模型的建立与观察

早期慢性淋巴水肿一般发生在术后4～6月内,常为进行性的,逐渐变硬,并不再消退。为研究有效的治疗方法,用动物形成后肢梗阻性淋巴水肿,成功率达88.89%。实验侧淋巴管造影示淋巴管阻塞早期主要是渗出性改变,晚期出现广泛的扩张、走行迂曲、皮肤逆流。对照侧淋巴管压低于同侧静脉压,实验侧淋巴管压高于同侧静脉压和对照侧淋巴管压。因此,在临床上确定淋巴管阻塞的位置和寻找功能性淋巴管是应用显微外科治疗淋巴水肿的关键。

THE PRODUCTION AND OBSERVATIONS OF A PRACTICAL MODEL OF OBSTRUCTIVE CHRONIC LYMPHOEDEMA IN DOG'S HIND LIMBS

The oedema established by our modification of the Danese and Olszewski techniques is an animal experimental model akin to human chronic lymphoedema.Eleven dogs were used.Early chronic lymphoedema. generally appeared four to six months later,had a tendency to be- come progressive and indurated,and did not regress.The rate of success was 88.89%.Lymphangiography showed obstructed and dilated lymphatics with increased exudation in early stage of lymphoedema,while in chronic stage,widespread dilated and tortuous lymphatics accompanied by lympha- tic incompetency and lymphostatic disorder were evident.A fine lympho- venous anastomosis(LVA)was found during the dissection.Lymphatic pressure was lower than the venous pressure in the control limb,but lym- phatic pressure in the treated limb was higher than the venous pressure and it was also higher than the control lymphatic pressure.The prerequ- isite of the successful model is the obstruction of all lymphatics in hind limb.All the factors above may influence the lymph-flow-rate,and the curative effect of LVA operations.