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Effects of tranexamic acid on fibrinolysis, fibrinogenolysis and amidolysis
Authors:A Takada  Y Makino  Y Takada
Institution:1. Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Zografou, Greece;2. Department of Gastroenterology, Red Cross Hospital of Athens, Greece;3. Product Development, GlaxoSmithKline, Ware, UK;1. Division of Cardiology, Department of Medical and Surgical Sciences, “Magna Graecia” University, Catanzaro, Italy;2. URT-CNR, Department of Medicine, Consiglio Nazionale delle Ricerche, Catanzaro, Italy;1. Institute of Environmental Toxicology, Yancheng Teachers University, Yancheng City, Jiangsu Province 224002, People''s Republic of China;2. School of Chemistry and Environmental Engineering, Yancheng Teachers University, Yancheng City, Jiangsu Province 224002, People''s Republic of China;1. Tissue Engineering and Cell Therapy Group (GITTC), School of Medicine, University of Antioquia, Colombia;2. Dermatology Department, School of Medicine, University of Antioquia, Colombia;3. Medical Research Institute, School of Medicine, University of Antioquia, Colombia;1. Department of Civil Engineering, University of Nebraska–Lincoln, Peter Kiewit Institute, Omaha, NE 68182-0178, USA;2. School of Natural Resources, University of Nebraska–Lincoln, Lincoln, NE 68583-0844, USA;3. Border Biomedical Research Center, University of Texas at El Paso, 500 W. University Ave., El Paso, TX 79902, USA;4. Department of Biological Sciences, University of Texas at El Paso, 500 W. University Ave., El Paso, TX 79902, USA;5. Department of Biology, University of Nebraska at Omaha, 6001 Dodge Street, Omaha, NE 68182-0040, USA;6. Department of Environmental, Agricultural and Occupational Health, University of Nebraska-Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198–6805, USA
Abstract:When Glu-plasminogen (Glu-plg) was activated by urokinase (UK) in the presence of fibrinogen or fibrinogen plus tranexamic acid (1 mM), or else tranexamic acid (1 mM), the activation as measured by the hydrolysis of S-2251 was enhanced by tranexamic acid or fibrinogen or both. When plasma or clotted plasma was activated by UK in the presence of 1 mM tranexamic acid, fibrinolysis was completely inhibited. When Lys-plg was activated by UK in the presence of tranexamic acid and fibrin or fibrinogen, fibrinolysis was completely inhibited by 1 mM tranexamic acid, but some inhibition of fibrinogenolysis was observed. The release of B beta 15-42 from fibrin in clotted plasma activated by UK was inhibited to some extent by 1 mM tranexamic acid. The release of B beta 15-42 from fibrin after UK-activation of Lys-plg was partly inhibited by tranexamic acid. In conclusion, tranexamic acid in the concentration of 1 mM enhanced amidolysis, but inhibted fibrinolysis measured by the generation of fibrin-degradation products. Fibrinogenolysis and the release of B beta 15-42 from fibrin were partly inhibited.
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