Intracortical 5,7-dihydroxytryptamine depletes brain serotonin concentrations without affecting spontaneous activity |
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Authors: | R S Black R G Robinson |
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Affiliation: | Departments of Psychiatry and Behavioral Science and Neuroscience Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA |
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Abstract: | Microinjections of either 2 or 4 micrograms of the serotonergic neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) were made into either the right or left frontal cortex of male rats pretreated with desmethylimipramine. Although both the 2 and 4 micrograms doses produced significant depletions of serotonin concentrations in the cortex and median raphe, neither dose produced a significant increase in spontaneous activity. This is in contrast to our findings with the noradrenergic neurotoxins, 6-hydroxydopamine and DSP-4, which produced hyperactivity following right but not left hemisphere injections. These findings do not rule out the involvement of 5-HT in the asymmetrically elicited hyperactivity but they do suggest some transmitter and neural pathway specificity to the lateralized response to cortical injury. |
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Keywords: | 5,7-Dihydroxytryptamine Asymmetry Lateralization Serotonin Behavior |
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