Extramammary Paget's cells: further evidence of sweat gland derivation |
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| Authors: | H Hamm T M Vroom B M Czarnetzki |
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| Affiliation: | 1. Dermatology, Toho University School of Medicine, Tokyo, Japan;2. Dermatology, Keio University School of Medicine, Tokyo, Japan;3. Dermatology, Ehime University School of Medicine, Ehime, Japan;4. Dermatology, University of Pennsylvania, Philadelphia, PA, USA;1. Department of Emergency Medicine, Bozok University Faculty of Medicine, Yozgat, Turkey;2. Department of Public Health, Faculty of Medicine, Bozok University, Yozgat, Turkey;3. Department of Biophysics and Biochemistry, Baku State University, Baku, Azerbaijan;4. Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran;5. Department of Pharmacology & Toxicology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran;6. Joint Ukraine-Azerbaijan International Research and Education Center of Nanobiotechnology and Functional Nanosystems, Drohobych, Ukraine & Baku, Azerbaijan;7. Institute of Radiation Problems, National Academy of Sciences of Azerbaijan, Baku, Azerbaijan;1. Institute of Meteorology and Water Management, National Research Institute, Kraków, Poland;2. Jagiellonian University, Faculty of Geography and Geology, Institute of Geography and Spatial Management, Kraków, Poland;1. Federal University of Rio de Janeiro, Rio de Janeiro, Brazil;2. Federal University of Paraná, Curitiba, Brazil;3. Medical School of Rio Preto and Ultra X, São José do Rio Preto, SP, Brazil;4. Santa Casa de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil;5. Santa Catarina Federal University, Florianópolis, Brazil;1. Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts;2. Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada;3. Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada;4. Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts;5. Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts;6. Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts;7. Department of Pathology, Brigham and Women''s Hospital, Harvard Medical School, Boston, Massachusetts;8. Breast Oncology Program, Dana-Farber/Brigham and Women’s Cancer Center, Boston, Massachusetts |
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| Abstract: | Tissue from a 66-year-old male patient with extramammary Paget's disease of the right side of the scrotum and the right groin was studied for the presence of several antigens with the immunoperoxidase technic. Adenokeratin (cytokeratin No. 18) and carcinoembryonic antigens were positive in Paget's cells, whereas squamokeratin (cytokeratin No. 10) was expressed only in normal epidermal cells. Langerhans cells were decreased in the region of the tumor. Many transferrin receptors were present on the tumor cells, indicating a high cellular proliferation rate. Enzyme histochemical studies of the extramammary Paget's cells showed positive reactions for several enzymes typical of sweat glands, except for leucine aminopeptidase, which was negative. A comparison with three other cases showed that these enzyme reactions varied greatly from case to case. Both immunohistochemical and enzyme histochemical findings provide further evidence that extramammary Paget's cells are related to sweat gland epithelial cells, with variable expression of cellular characteristics. |
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