绝经前后妇女雌激素水平与颈动脉内膜中层厚度的关系

目的:探讨绝经前后妇女雌激素水平、抗氧化能力与动脉粥样硬化斑块的关系。方法:选取绝经前后健康妇女各40例,分为绝经后组和绝经前组,观察各组颈动脉内膜中层厚度(IMT)和雌二醇(E2)浓度,并测定血脂、羟自由基、丙二醛和超氧化物歧化酶的水平。结果:绝经后组IMT增加,E2水平降低,两者变化显著相关,同时绝经后组抗氧化能力下降,而低密度脂蛋白水平升高。结论:女性低雌激素状态易引起颈动脉内膜增厚,这可能与低雌激素状态引起抗氧化能力下降和血脂升高有关。

Relationship between estrogen and carotid arterial intima-media thickness in pre-and post-menopausal women

Objective To investigate the relationship of estrogen and antioxidation with atherosclerotic plaque in pre- and post-menopausal women. Methods Carotid arterial intima-media thickness (IMT) and serum concentrations of estrogen were detected in 40 premenopausal and 40 postmenopausal women, so were levels of lipids, hydroxy radical, maleic dialdehyde, and superoxide dismutase. Results In the postmenopause group, the average IMT was increased while estrogen levels were decreased, showing a significant negative correlation. A decrease in antioxidation and an increase in LDL levels also occurred. Conclusion Low estrogen level in postmenopausal women is more likely to cause carotid arterial IMT, which may be involved in a decreased antioxidation and an increased lipid level.