ABO血型与胃癌发生风险的病例-对照研究及meta分析

目的 通过病例-对照研究及meta分析探讨ABO血型系统与胃癌发生风险的关系。方法 收集第二军医大学长海医院930例胃癌患者及8 426例非胃癌患者进行病例-对照研究；检索PubMed数据库，检索起始时间不限，截止时间为2013年12月31日。将笔者所做病例-对照研究一并纳入分析，由2名研究者独立筛取文献并提取数据，采用纽卡斯尔-渥太华量表（NOS）进行文献质量评价，采用Meta-Analyst 3.13软件进行meta分析。结果 病例-对照研究提示： 血型A是胃癌发生的可能危险因素（OR=1.58，95%CI为1.37~1.81）；meta分析结果显示： 血型A较非A血型人群胃癌发生风险有所增加（OR=1.28，95%CI为1.01~1.62），血型O发生胃癌风险低于非O血型人群（OR=0.84，95%CI为0.73~0.96），但亚组分析发现结果在国内外人群中存在差异。结论 ABO血型系统与胃癌发生风险存在关联，血型A是胃癌发生的可能危险因素之一。

ABO blood group and the risk of gastric cancer: a case-control study and meta-analysis

Objective To evaluate the relationship between ABO blood group system and the risk of gastric cancer by case-control study and meta-analysis. Methods In our case-control study, 930 cases of gastric cancer were enrolled and 8 426 cases with other diseases were taken as controls from Changhai Hospital. PubMed were searched with unlimited initial time and the cutoff time on December 31, 2013; and our case-control study was also included. Two reviewers evaluated the quality of the included case-control studies by Newcastle-Ottawa scale (NOS) and extracted the data independently. The meta-analysis was performed by Meta-Analyst 3.13 software. Results The case-control study showed that blood type A might be a risk factor of gastric cancer (OR=1.58;95%CI: 1.37-1.81). The results of meta-analysis showed that the risk of gastric cancer of blood group A was significantly higher than that of non-A groups (OR=1.28; 95%CI: 1.01-1.62); meanwhile, blood group O demonstrated a lower risk of gastric cancer compared with non-O groups (OR=0.84;95%CI: 0.73-0.96); subgroup analysis found differences between home population and foreign population. Conclusion ABO blood group system is associated with the risk of gastric cancer, and type A might be one of the risk factors of gastric cancer.