消化道癌P-糖蛋白的表达及与化疗反应的关系

目的:研究P糖蛋白(Pgp)在消化道常见癌组织中的表达,以指导临床化疗。方法:收集我院2002年1月～2002年10月术前未经治疗的消化道癌切除标本150例,以SP免疫组化方法检测其Pgp表达。结果:胃腺癌、大肠腺癌Pgp表达阳性率及强度均高于食管鳞癌,差异有统计学意义,P<0.01。Pgp阳性表达与消化道癌患者的性别、年龄、癌分化程度及淋巴结转移均无关,P>0.05。结论:Pgp在消化道常见癌组织中表达增高,检测消化道癌(尤其是胃肠道腺癌)的Pgp表达对选择合理的化疗方案和判断预后有重要作用。

P-glycoprotein expression in carcinoma of digestive tract and the role in chemotherapy

OBJECTIVE: To ascertain the frequency of P-glycoprotein (P-gp) expression in three common carcinomas of digestive tract in order to direct clinical therapy. METHODS:One hundred and fifty surgically resected tumor specimens confirmed pathologically to be malignant digestive tract carcinomas from preoperatively untreated carcinoma patients were studied. Expression of P-gp was examined by SP immunohistochemistry.RESULTS:The positive rate and intensity of P-gp expression in gastric and colorectal adenocarcinomas were higher than those in squamous cell carcinoma of esophagus, the difference was significant,P<0.01. No correlation was observed with gender, age, differentiation and lymph node metastasis,P>0.05. CONCLUSIONS:Primary P-gp expression is related to the frequent occurrence in common carcinomas of digestive tract. Examining P-gp expression in digestive carcinomas, especially gastric and colorectal adenocarcinomas, plays an important role in orientating the cancer treatment and predicting prognosis.