| 雌激素受体基因IVS401T/C变异在黑龙江省老年骨质疏松症发病中的作用 |
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| 引用本文： | 徐静华. 雌激素受体基因IVS401T/C变异在黑龙江省老年骨质疏松症发病中的作用[J]. 黑龙江医学, 2009, 33(6): 427-429 |
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| 作者姓名： | 徐静华 |
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| 作者单位： | 武警黄金第一总队医院内科,黑龙江,哈尔滨,150086 |
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| 摘 要： | 目的研究雌激素受体(ER)基因IVS1-401T/C变异与黑龙江省老年老年骨质疏松症的关系,以确定机体对雌激素作用的反应是否与其有关。方法对老年骨质疏松症患者及健康对照组采用PvuⅡ限制性核酸内切酶酶切目标片段判断ERα基因型,计算基因频率并进行比较。结果骨质疏松症患者中,该位点核苷酸出现胞嘧啶核苷酸(C)的频率明显低于对照组(P<0.05),ERT/T基因型是骨质疏松患者的独立危险因素,单纯分析女性受试者结果与之一致。结论ER基因IVS1-401T/C变异与黑龙江省老年骨质疏松症的发生有密切关系。
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| 关 键 词： | 雌激素受体 多态性 基因 骨质疏松症 |
The Role of ER. IVS1-401T/C Variation in the Occurrence of Geriatric Osteoporosis in Heilongjiang Humans |
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| XU Jing-hua. The Role of ER. IVS1-401T/C Variation in the Occurrence of Geriatric Osteoporosis in Heilongjiang Humans[J]. Heilongjiang Medical Journal, 2009, 33(6): 427-429 |
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| Authors: | XU Jing-hua |
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| Affiliation: | XU Jing- hua ( Gold Corps Hospital of Chinese People＇ s Armed Polico Forces, Harbin 150086, China ) |
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| Abstract: | Objective To clarify whether IVS1 -401T/C variation in ER. gene affects the occurrence of geriatric osteo- porosis in Heilongjiang province. Methods Osteoporosis patients and healthy volunteers were cheesed . By using neuclericase PvuⅡ, this variation can be divided into three types： T/T, T/C, C/C. Results Frequency of C/C is significantly fewer in osteoporosis patients. The appearance of T is an independent risk factor in osteoporosis. Conclusion IVS1 - 401T/C variation in ER gene is closely associated with the occurrence of osteoporosis. |
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| Keywords: | Estrogen receptor Polymorphism Gene Osteopomsis |
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