右美托咪定复合纳布啡对腹部大手术患者术后早期急性疼痛治疗效果观察

目的观察对比单用纳布啡与右美托咪定联合纳布啡对腹部大手术患者术后早期急性疼痛的治疗效果。方法选取某院2018年1月~2019年5月期间行腹部大手术病例共110例,随机分为试验组与对照组,每组55例。术后给予对照组患者纳布啡单用镇痛治疗;试验组患者给予右美托咪定复合纳布啡联合镇痛治疗。记录不同时间段两组手术患者时刻平均动脉压(Mean Arterial Pressure,MAP)以及心率(Heart Rate,HR)变化情况;采取视觉模拟量表(VAS)对两组手术患者各时间段的疼痛表现作量化评价,同时记录两组患者镇痛治疗期间所发生的不良反应。结果对照组术后各时间段MAP、HR变化值均高于试验组,差异有统计学意义(P<0.05);对照组术后各时间段VAS评分值均高于试验组,差异有统计学意义(P<0.05)。对照组不良反应发生率稍高于试验组,差异不存在统计学意义(P>0.05)。结论对于实行腹部大手术患者而言,采取右美托咪定复合纳布啡与单用纳布啡相比可更有效地缓解术后早期急性疼痛反应,且不会导致不良反应发生率升高。

Observation on the effect of dexmedetomidine combined with nalbuphine in the treatment of early acute pain after abdominal surgery

Objective To observe and compare the therapeutic effect of nalbuphine alone and dexmedetomidine combined with nalbuphine on early acute pain after abdominal surgery.Methods From January 2018 to may 2019,a total of 110 cases of major abdominal surgery were randomly divided into experimental group and control group,with 55 cases in each group.The patients in the experimental group were treated with dexmedetomidine combined with nalbuphine.The changes of mean arterial pressure(MAP)and heart rate(HR)were recorded in two groups at different times.Visual analogue scale(VAS)was used to evaluate the pain performance of the two groups in different time periods,and the adverse reactions during the analgesia treatment were recorded.Results The changes of MAP and HR in the control group were significantly higher than those in the experimental group.The VAS score of the patients in the control group was higher than that of the patients in the experimental group.The incidence of adverse reactions in the control group was slightly higher than that in the experimental group,the difference was not statistically significant.Conclusion For patients undergoing major abdominal surgery,dexmedetomidine combined with nalbuphine is more effective than single nalbuphine in alleviating early postoperative acute pain,and will not lead to an increase in the incidence of adverse reactions.