坦度螺酮用于冠心病介入治疗后并发焦虑症效果观察

【目的】探讨冠心病介入治疗后并发焦虑症患者坦度罗酮干预治疗效果观察。【方法】选取2012年9月-2013年9月在我院行冠心病介入治疗后焦虑症患者82例;按照随机数字表法分为治疗组和对照组各41例,两组均给予介入术后常规治疗,对照组给予心理干预,观察组在对照组的基础上给予枸橼酸坦度螺酮（律康）,10-30mg/d,每4周复诊1次,每次复查心电图、判断冠心病的临床疗效,测定症状自评量表（symptom checklist 90,SCL—90）和Zung焦虑自评量表（self—rating anxiety scale,SAS）评分,观察不良反应发生情况。【结果】治疗组和对照组总有效率分别为（95.12%,85.37%）,治疗组明显高于对照组,差异具有统计学意义（P〈0.05）;治疗组治疗4周、8周后SCL—90评分（22.23±3.24,21.20±3.01）和SAS评分（51.75±4.84,48.80±4.35）均较治疗前明显降低,且明显低于对照组,差异具有统计学意义（P〈0.05）;经Logistic回归分析显示：SAS和SCL—90评分均是冠心病心绞痛症状改善的独立影响因素,治疗组无严重不良反应事件发生。【结论】坦度罗酮可显著改善冠心病介入治疗后焦虑症患者的心理健康水平,减轻负面情绪对身体健康的影响,从而提高介入疗效。

Effect of Tandospirone on anxiety disorder in patients after percutaneous coronary intervention

【Objective】To explore the therapeutic ellecl of Tandospiione on anxiety disorder in coronary heart disease（CHI）） patients after treated by percutaneous coronary intervention（PCI）.【Method】 A total of 82 patients with anxiety disorder after PCI treatment from September 2012 to September 2013 were enrolled,and randomly divided into treatment group and control group（n = 41 for each group）.The control group received conventional psychological intervention,while the Irealmenl group received convenlioual psychological intervention plus Tandospirone（10 mg~30 mg/day）.All patients were followed up every 4 weeks to check the clinical manifestations and the score of symptom self-assessment scale（SCL- 90） and Zung self rating anxiety scale（SAS）.as well as the potential side effects of drug Irealmenl.【 Results】 The total efficacy of anxiety relieved in treatment group and control group was 95.12%and 85.37%respectively,which was significantly higher in the Tandospirone group（P〈0.05）..After treatment,the score of SCL-90 and SAS of the Irealmenl group was significantly decreased,and significantly lower than the score of control group.The difference also had statistical significance（P〈0.05）.Logistic regression analysis revealed that the SAS and SCL- 90 scores were independent clinical factors that were associated with clinical improvement of angina symptoms.There was no serious adverse events in the Irealmenl group.【Conclusion】Tandospirone could significantly improve the level of menial health of patients with anxiety disorder after PCI and mitigate the effects of negative emotions,which in turn may improve the therapeutic effect of PCI in CHD patients.