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| 活血、益气、化痰中药对ApoE基因敲除小鼠主动脉粥样硬化斑块稳定性的影响 | |
| 引用本文： | 周明学,徐浩,陈可冀,潘琳,郭艳茹,文川. 活血、益气、化痰中药对ApoE基因敲除小鼠主动脉粥样硬化斑块稳定性的影响[J]. 中医杂志, 2008, 49(11): 1024-1027 |
| 作者姓名： | 周明学 徐浩 陈可冀 潘琳 郭艳茹 文川 |
| 作者单位： | 1. 中国中医科学院,北京市东城区东直门内南小街16号,100700 2. 中日友好医院全国中西医结合心血管病中心、临床医学研究所中心实验室 3. 中国中医科学院西苑医院心血管病中心 |
| 摘 要： | 目的 以中药提取物为切入点,观察中医不同治法对ApoE基因敲除(ApoE-/-)小鼠主动脉斑块稳定性的影响.方法 70只ApoE-/-小鼠高脂喂养13周,随机分为活血组(丹参酮),益气组(西洋参茎叶总皂苷)、化痰组(瓜萎提取物)、模型组、阳性对照组(辛伐他汀).予药物治疗13周后,采用形态学方法 ,利用易损指数综合评价药物对斑块稳定性的影响.结果 与模型组比较,3个中药组小鼠斑块易损指数均有所降低,纤维帽长度/斑块内膜比值均有所增加,瓜蒌提取物组埋藏纤维帽数目显著减少.结论 活血、益气、化痰中药有效部位均可通过改善斑块内部成分稳定斑块,化痰中药瓜篓提取物在减少斑块破裂次数方面可能更有优势,其具体作用值得深入研究. |
| 关 键 词： | 易损斑块 动脉粥样硬化 易损指数 化痰 活血 益气 |
Effect of Herbs to Activate Blood,Reinforce Qi and Dissolve Phlegm on Atherosclerotic Plaque Stability in Aorta of ApoE-gene Knockout Mice |
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| ZHOU Ming-xue,XU Hao,CHEN Ke-ji,et al.. Effect of Herbs to Activate Blood,Reinforce Qi and Dissolve Phlegm on Atherosclerotic Plaque Stability in Aorta of ApoE-gene Knockout Mice[J]. Journal of Traditional Chinese Medicine, 2008, 49(11): 1024-1027 | |
| Authors: | ZHOU Ming-xue XU Hao CHEN Ke-ji et al. |
| Affiliation: | ZHOU Ming-xue1,XU Hao2,CHEN Ke-ji3,et al.(1.China Academy of Chinese Medical Sciences,Beijing 100700,2.Department of National Integrative Medicine Center for Cardiovascular Disease,China-Japan Friendship Hospital,3.Xiyuan Hospital,China Academy of Chinese Medical Sciences) |
| Abstract: | Objective To observe the effects of different herbal extractives on vulnerable atherosclerotic plaque stability in the aortic roots of fat-fed ApoE knockout mice.Methods Sixty ApoE knockout mice were fed a high-fat diet for 13 weeks until the mature atherosclerotic plaques formed.Thereafter,they were randomized into five groups:activating blood circulation group (treated with tanshinone),reinforcing qi group (treated with panaxquinquefoliumsaponin),dissolving phlegm group (treated with snakegourd fruit extr... |
| Keywords: | Vulnerable plaque Atherosclerosis Vulnerability index Dissolving phlegm Activating blood Reinforcing qi |
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