Synthesis and analgesic activity of (2,3-diphenyl-1H-indol-5-YL)piperazin-1-yl methanone derivatives |
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| Authors: | A. O. H. El-Nezhawy S. I. El-Naem S. A. Galal H. I. El-Diwani O. M. E. Abdel Salam A. R. Baiomy |
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| Affiliation: | (1) Chemistry of Natural and Microbial Products Department, National Research Center, Dokki, Cairo, Egypt;(2) Department of Pharmacology, National Research Center, Dokki, Cairo, Egypt |
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| Abstract: | Series of 1,4-disubstituted piperazine and of N,N-disubstituted ethylenediamine having the 2,3-diphenyl- 1H-indole-5-carbonyl group as one of the two substituents were prepared. Compounds 3, 4, 11, 15 – 17, and 20 – 22 were tested for analgesic activity. After ip administration all compounds induced significant visceral antinociceptive activities where acetic acid-induced writhing was significantly reduced by all compounds. |
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| Keywords: | 2,3-diphenylindole piperazine ethylenediamine analgesic activity |
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