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Human Gut Microbiota and Its Metabolites Impact Immune Responses in COVID-19 and Its Complications
Affiliation:1. Department of Gastroenterological Endoscopy, Tokyo Medical University, Tokyo, Japan;2. Department of Gastroenterology and Hepatology, National Center for Global Health and Medicine, Tokyo, Japan;3. Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan;4. Laboratory for Microbiome Sciences, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan;5. Mechanism-based Research Laboratory, Ezaki Glico Co, Ltd, Osaka, Japan;6. Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan;7. Genome Medical Sciences Project, National Center for Global Health and Medicine, Ichikawa, Japan;8. Department of Viral Pathogenesis and Controls, National Center for Global Health and Medicine, Ichikawa, Japan;9. Division of Respiratory Medicine, National Center for Global Health and Medicine, Tokyo, Japan;10. Department of Clinical Research Strategic Planning Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan;11. Pathogenic Microbe Laboratory, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan;12. Department of Parasitology, National Institute of Infectious Diseases, Tokyo, Japan;13. Department of Medicine and Therapeutics, Institute of Digestive Disease, State Key Laboratory of Digestive Diseases, LKS Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China;14. Microbiota I-Center, Hong Kong, China;15. Center for Gut Microbiota Research, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China;16. Department of Gastroenterology and Hepatology, National Center for Global Health and Medicine, Kohnodai Hospital, Tokyo, Japan;17. Department of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan
Abstract:
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  • Keywords:Gut Microbiome  Fecal Metabolome  Cytokine Storm  Gut-Lung Axis  4D"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0035"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Disease, Drug, Diet, Daily Life  AUC"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0045"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  area under the curve  BCAA"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0055"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  branched chain amino acid  BMI"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0065"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  body mass index  bp"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0075"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  base pairs  COPD"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0085"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  chronic obstructive pulmonary disease  DM"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0095"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  diabetes mellitus  FDR"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0105"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  false discovery rate  IBD"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0115"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  inflammatory bowel disease  IL"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0125"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  interleukin  KEGG"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0135"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Kyoto Encyclopedia of Genes and Genomes  KO"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0145"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Kyoto Encyclopedia of Genes and Genomes orthology  NCGM"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0155"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  National Center for Global Health and Medicine  PPI"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0165"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  proton pump inhibitor  RA"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0175"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  rheumatoid arthritis  SCFA"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0185"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  short-chain fatty acid  saturation of peripheral oxygen  WBC"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0205"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  white blood cell
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