Diagnostic Value and Prognostic Significance of Pleural C-Reactive Protein in Lung Cancer Patients with Malignant Pleural Effusions |
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Authors: | Do-Sim Park Dong Kim Ki-Eun Hwang Yu-Ri Hwang Chul Park Chang-Hwan Seol Kyung-Hwa Cho Byoung-Ryun Kim Seong-Hoon Park Eun-Taik Jeong Hak-Ryul Kim |
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Affiliation: | 1.Department of Laboratory Medicine, Institute of Wonkwang Medical Science, Wonkwang University School of Medicine, Iksan, Korea.;2.Department of Internal Medicine, Institute of Wonkwang Medical Science, Wonkwang University School of Medicine, Iksan, Korea.;3.Department of Obstetrics & Gynecology, Wonkwang University School of Medicine, Iksan, Korea.;4.Department of Radiology, Wonkwang University School of Medicine, Iksan, Korea. |
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Abstract: | PurposeC-reactive protein (CRP) has been implicated in various inflammatory and advanced malignant states. Increased serum CRP (s-CRP) levels have been shown to be associated with independent prognostic factors for survival in patients with advanced lung cancer. However, only few studies have focused on the role of CRP in pleural effusions. This study aimed to evaluate the diagnostic and prognostic value of pleural CRP (p-CRP) in lung cancer patients with malignant pleural effusion (MPE).Materials and MethodsPleural effusion (PE) samples were collected from patients with MPE (68 lung cancers; 12 extrathoracic tumors), and from 68 patients with various benign conditions (31 with pneumonia; 37 with tuberculosis). Concentrations of p- and s-CRP were measured by enzyme-linked immunosorbent assay. CRP level in pleural fluid and its association with survival were examined.Resultsp-CRP levels correlated with s-CRP levels (r=0.82, p<0.0001). For the differential diagnosis of MPE and benign PE, the area under the receiver operating characteristic curve was greater for p-CRP (0.86) than for s-CRP (0.77). High p-CRP expression significantly correlated with shorter overall survival (p=0.006). P-CRP was independent prognostic factor significantly associated with overall survival on multivariated analysis (p=0.0001). The relative risk of death for lung cancer patients with high p-CRP levels was 3.909 (95% confidence interval, 2.000-7.639).ConclusionP-CRP is superior to s-CRP in determining pleural fluid etiology. Quantitative measurement of p-CRP might be a useful complementary diagnostic and prognostic test for lung cancer patients with MPE. |
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Keywords: | Pleural CRP diagnosis prognosis lung cancer pleural effusion |
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