Interleukins in glioblastoma pathophysiology: implications for therapy |
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| Authors: | YT Yeung KL McDonald T Grewal L Munoz |
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| Affiliation: | 1.Faculty of Pharmacy, University of Sydney, Sydney, NSW, Australia;2.Cure For Life Neuro-Oncology Group, Prince of Wales Clinical School, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia;3.School of Medical Sciences, Discipline of Pharmacology, University of Sydney, Sydney, NSW, Australia |
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| Abstract: | Despite considerable amount of research, the poor prognosis of patients diagnosed with glioblastoma multiforme (GBM) critically needs new drug development to improve clinical outcomes. The development of an inflammatory microenvironment has long been considered important in the initiation and progression of glioblastoma; however, the success of developing therapeutic approaches to target inflammation for GBM therapy has yet been limited. Here, we summarize the accumulating evidence supporting a role for inflammation in the pathogenesis of glioblastoma, discuss anti-inflammatory targets that could be relevant for GBM treatment and provide a perspective on the challenges faced in the development of drugs that target GBM inflammation. In particular, we will review the function of IL-1β, IL-6 and IL-8 as well as the potential of kinase inhibitors targeting key players in inflammatory cell signalling cascades such as JAK, JNK and p38 MAPK. |
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| Keywords: | glioblastoma tumour microenvironment ILs inflammation kinase inhibitors |
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